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#‼️PHARMACOLOGY > CNS DRUGS - ANTIPSYCHOTICS AND LITHIUM > Flashcards

CNS DRUGS - ANTIPSYCHOTICS AND LITHIUM Flashcards

1
Q

TYPICAL (CLASSICAL) ANTIPSYCHOTICS MOA

A

MOA: Block more D2 receptors > 5HT 2A receptors

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2
Q

TYPICAL OR ATYPICAL?

Addresses positive symptoms (Hallucinations) of schizophrenia but not much effect on negative symptoms (emotional blunting, social withdrawal, lack of motivation)

A

TYPICAL (CLASSICAL) ANTIPSYCHOTICS

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3
Q

High potency typical antipsychotics (i.e. Haloperidol, droperidol): higher chances of causing ______

A

extrapyramidal symptoms (EPS)

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4
Q

Low potency typical antipsychotics (i.e. Thioridizine, Chlorpromazine): lower chances of causing EPS, more likely to cause _______

A

sedation and postural hypotension (due to alpha receptor blockade)

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5
Q

ATYPICAL ANTIPSYCHOTICS MOA

A

MOA: Block 5HT 2A receptors > D 2 receptors

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6
Q

Atypical antipsychotics address both ________

A

positive and negative effects of schizophrenia

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7
Q

TYPICAL OR ATYPICAL?

lesser propensity to cause EPS compared to its typical counterparts, but has a higher propensity in causing metabolic derangements (weight gain, endocrine problems)

A

ATYPICAL ANTIPSYCHOTICS

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8
Q

schizophrenia is caused by a relative _____ of dopamine in specific neuronal tracts in the brain

EXCESS OR LACK?

A

EXCESS

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9
Q

Typical antipsychotics (Phenothiazine)

A

CHLORPROMAZINE [C]

THIOTHEXENE [C] (Thioxanthene), FLUPENTIXOL (Thioxantene), PROMETHAZINE, PROCHLORPERAZINE [C], LEVOMEPROMAZINE

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10
Q

typical antipsychotic that can cause Corneal and lens deposits

A

CHLORPROMAZINE [C]

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11
Q

Typical antipsychotic (Piperdine)

A

THIORIDAZINE [C]

FLUPHENAZINE [C], PERPHENAZINE [C], TRIFLUOPERAZINE [C]

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12
Q

typical anti psychotic that can cause Retinal Deposits

A

THIORIDAZINE [C]

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13
Q

_________ has the most muscarinic blockade therefore has the least EPS amongst the typical antipsychotics

A

THIORIDAZINE [C]

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14
Q

differentiate CHLORPROMAZINE AND CHLORPROPAMIDE

A

CHLORPROMAZINE - typical anti psychotic

CHLORPROPAMIDE - surfonylurea

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15
Q

Typical antipsychotic (butyrophenone)

A

HALOPERIDOL [C]

DROPERIDOL [C]

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16
Q

_______ causes the most extrapyramidal symptoms and neuroleptic malignant syndrome of all typical anti-psychotics

A

HALOPERIDOL [C]

17
Q

DOC for refractory and suicidal schizophrenia

A

CLOZAPINE [B]

18
Q

Atypical antipsychotic (Dibenzodiazepine)

A

CLOZAPINE [B]

19
Q

highest tendency to cause weight gain amongst your atypicals

A

Clozapine and Olanzapine

20
Q

Only antipsychotic that reduces the risk of suicide

A

CLOZAPINE [B]

21
Q

feared complications of clozapine

A

Agranulocytosis and seizures

22
Q

cause MINIMAL or NO increases in prolactin and has a reduced rish of EPS (reflected by minimal D2 antagonism)

A

Olanzapine, Quetiapine and Aripiprazole

23
Q

atypicals that are LEAST LIEKLY to cause tardive dyskinesia

A

Quetiapine and Clozapine

24
Q

Drug used for sleep maintenance and promotion

A

QUETIAPINE

25
Q

compared to all the other atypicals, has the highest propensity for causing hyperprolactinemia (amenorrhea, galactorrhea)

A

RISPERIDONE [C]

26
Q

Only antipsychotic approved for schizophrenia in the

youth

A

RISPERIDONE [C]

27
Q

atypical antipsychotic that has the greatest risk for QT prolongation (and hence don’t combine with drugs that will have the same effect i.e thioridazine, class I and III anti arrhythmics)

A

ZIPRASIDONE [C]

28
Q

Least sedating atypical antipsychotic

A

ARIPIPRAZOLE [C]

29
Q

What are the features of neuroleptic malignant syndrome?

Mnemonic: “FEVER”

A

Fever

Elevated CPK

Rigidity

Encephalopathy

Vitals unstable

30
Q

give examples of ATYPICAL ANTIPSYCHOTICS

A

Amisulpride Aripiprazole Asenapine Blonanserin Carpipramine Clocapramine Clotiapine Clozapine Iloperidone Lurasidone Mosapramine Olanzapine Paliperidone Perospirone Quetiapine Remoxipride Risperidone Sertindole Ziprasidone Zotepine

31
Q

drug that causes EBSTEIN ANOMALY

A

LITHIUM

32
Q

DOC for bipolar disorder

A

Lithium

33
Q

Lithium mnemonic lifted from USMLE:

“LiTHIUM”

A

Low Thyroid hormone, Heart (Ebstein anomaly), Insipidus (nephrogenic diabetes insipidus, Unintentional Movement (tremor)

34
Q

NEWER AGENTS USED FOR BIPOLAR DISORDER

A

Carbamazepine

Lamotrigine

Valproic Acid / Divalproex

#‼️PHARMACOLOGY (31 decks)

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