CNS DRUGS - OPIOID ANALGESICS AND ANTAGONISTS Flashcards
opioid with the SHORTEST half-life
REMIFENTANIL = shortest half-life (3-4 mins)
opioid with the LONGEST half-life
BUPRENORPHINE = longest half-life (4-8 hrs)
Side effects of opioids with minimal or no tolerance (an effect that does not diminish despite continued use)
Miosis
Constipation
Convulsions
MEPERIDINE DOES NOT CAUSE MIOSIS, rather it
MYDRIASIS
opioid analgesic (full agonist) that can cause Seizures and delirium
MEPERIDINE [C]
has the most pronounced anti-shivering effect (a2 antagonism)
MEPERIDINE
opioid analgesic used for cough
DEXTROMETHORPHAN
CODEINE
Morphine side effects:
“MORPHINE”
Miosis
Out of it
Respiratory depression
Pruritus
Hypotension and Headache
In frequency
Nausea
Emesis
Opioid analgesics (FULL AGONISTS)
MORPHINE [C], HYDROMORPHONE [C] OXYMORPHONE [C] , HEROIN (Synthetic derivatives of Morphine)
FENTANYL [C], SUFENTANIL (5-10x more potent than fentanyl), ALFENTANIL(1/5th to 1/10th as potent as fentanyl) [C], REMIFENTANIL (same potency as fentanyl) [C], OHMEFENTANYL
MEPERIDINE [C]
METHADONE [C], LEVOMETHADYL ACETATE, LEVORPHANOL [C]
OPIOID ANALGESICS (PARTIAL AGONISTS)
HYDROCODONE [C], OXYCODONE [B, may be C if given in combination], DIHYDROCODEINE
DEXTROMETHORPHAN [C], CODEINE
OPIOID ANALGESICS (WEAK AGONISTS)
PROPOXYPHENE, LEVOPROPOXYPHENE [C], DEXTROPROPOXYPHENE
OPIOID ANALGESICS (MIXED AGONIST-ANTAGONIST)
BUPRENORPHINE [C], NALBUPHINE [B], BUTORPHANOL [C], PENTAZOCINE [C], LEVALLORPHAN [B]
OPIOID ANTAGONISTS
NALOXONE [C], NALTREXONE [C], NALMEFENE [B], ALVIMOPAN [B], METHYLNALTREXONE [B]
DOC for Opioid overdose
NALOXONE
DOC for Opioid and alcohol dependence
NALTREXONE
