CARDIO - HEART FAILURE

Question 1

What drugs have been shown to improve survival in cases of heart failure?

Answer 1

ABA! Buhay ka pa!

ACE inhibitors

Beta-blockers

Aldosterone Antagonists (Spironolactone.)

Question 2

If digoxin antibodies are not available, what canbe given as substitute?

Answer 2

Bile Acid binding resins (Colestipol, Cholestyramine)

Question 3

an antihypertensive drug used in combination with Valsartan for Heart Failure. It is prodrug that is activated to Sacubitrilat, which inhibits the enzyme Neprilysin (responsible for the degradation of atrial and brain natriuretic peptide – two BP lowering peptides that work mainly by reducing blood volume.

Answer 3

SACUBITRIL

Question 4

DRUGS USED IN HF

Answer 4

Question 5

Arrhythmogenesis of digoxin is increased by

Answer 5

hypokalemia, hypomagnesemia and hypercalcemia

o loop diuretics and thiazides may significantly reduce serum potassium and precipitate digitalis toxicity

o digitalis-induced vomiting may deplete serum magnesium and similarly facilitate toxicity

Question 6

most common ECG change seen in Digoxin toxicity

Answer 6

Premature Ventricular Contractions (PVCs)

Question 7

DIGOXIN MOA

Answer 7

Inhibits Na + /K + ATPase; Increases intracellular Ca 2+ , increasing cardiac contractility