CARDIO - ANTIARRHYTHMICS

Question 1

Group 1C

Answer 1

no effect on AP duration

“FEMPro”

FLECAINIDE

ENCAINIDE

MORICIZINE

PROPAFENONE

Question 2

hallmark is prolongation of the AP duration

o caused by blockade of I K potassium channels that are responsible for the repolarization of the AP

o results in an increase in ERP and reduces the ability of the heart to respond to rapid tachycardias

Answer 2

CLASS 3 ANTIARRHYTHMICS

Question 3

CLASS 2 ANTIARRHYTHMICS act on what phase of the cardiac cycle?

Answer 3

Phase 4

Question 4

ANTIARRHYTHMIC THAT CAN CAUSE Thyroid dysfunction (hyper- or hypo-)

Answer 4

AMIODARONE

Question 5

Treatment of Class 1A Overdose

Answer 5

• Sodium Lactate to reverse drug-induced arrhythmias
• Pressor sympathomimetics to reverse drug-induced hypotension if indicated

Question 6

for refractory arrhythmias

Answer 6

Class 1C

Question 7

DOC for ventricular arrhythmias post-myocardial infarction

Answer 7

CLASS 1B: LIDOCAINE [B], MEXILETINE [C], TOCAINIDE [C], PHENYTOIN [D]

Question 8

Group 1A

Answer 8

prolong the AP duration

“QPD”

QUINIDINE

PROCAINAMIDE

DISOPYRAMIDE

Question 9

DRUGS USED FOR CARDIAC ARRHYTHMIA

Answer 9

Question 10

contraindicated in post MI arrhythmias

Answer 10

Class IC

Question 11

most effective since it can do all MOA of class 1 to 4.

Answer 11

Amiodarone

However, it is also the most toxic and has the most numerous side effects.

Question 12

used antiarrhythmics for wolf parkinson white

Answer 12

Procainamide and Amiodarone

Question 13

Sotalol and Amiodarone also have group____ effects

Answer 13

2

Question 14

CLASS 2 MOA

Answer 14

Beta-adrenoceptor blockers

Question 15

beta-blocker anti-arrhythmic that has Class 3 properties

Answer 15

Sotalol

Question 16

CLASS 3 ANTIARRHYTHMICS act on what phase of the cardiac AP?

Answer 16

Phase 3

Question 17

DOC FOR Digoxin-induced arrhythmias

Answer 17

CLASS 1B: LIDOCAINE [B], MEXILETINE [C], TOCAINIDE [C], PHENYTOIN [D]

Question 18

Class 3

Answer 18

“VAIDDS”

VERNAKALANT

AMIODARONE

IBUTILIDE

DOFETILIDE

DRONEDARONE

SOTALOL

Question 19

Why are dihydropyridine calcium channel blockers not useful as antiarrhythmics?

Answer 19

• dihydropyridine CCBs evoke compensatory sympathetic discharge which facilitates arrhythmias rather than terminating them.
• dihydropyridine CCBs can cause reflex tachycardia and are pro-arrhythmogenic.

Question 20

Goup 1B

Answer 20

Shorten the AP duration

“LiMeToP”

LIDOCAINE

PHENYTOIN

TOCAINIDE

MEXILETINE

Question 21

most arrhythmogenic among the class1 anti-arrhythmics that’s why they’re only used for refractory arrhythmias

Answer 21

Class 1C

Question 22

ECG morphology of Class 3

Answer 22

increase in QT interval

Question 23

CLASS 4 MOA

Answer 23

Calcium channel blockers

Question 24

AMIODARONE TOXICITY

Answer 24

Pulmonary fibrosis

Paresthesia

Tremors

Thyroid dysfunction

Corneal deposits

Skin deposits

Question 25

Class 1 acts on what phase of the cardiac action potential?

Answer 25

Phase 0

Question 26

CLASS 1 MOA

Answer 26

Sodium channel blockers

Question 27

CLASS 3 MOA

Answer 27

Potassium channel blockers

Question 28

What are the major subgroups of beta-blockers?

Answer 28

Question 29

DOC for paroxysmal supraventricular tachycardia

Answer 29

ADENOSINE