CARDIO - ANTIARRHYTHMICS Flashcards
Group 1C
no effect on AP duration
“FEMPro”
FLECAINIDE
ENCAINIDE
MORICIZINE
PROPAFENONE
hallmark is prolongation of the AP duration
o caused by blockade of I K potassium channels that are responsible for the repolarization of the AP
o results in an increase in ERP and reduces the ability of the heart to respond to rapid tachycardias
CLASS 3 ANTIARRHYTHMICS
CLASS 2 ANTIARRHYTHMICS act on what phase of the cardiac cycle?
Phase 4
ANTIARRHYTHMIC THAT CAN CAUSE Thyroid dysfunction (hyper- or hypo-)
AMIODARONE
Treatment of Class 1A Overdose
- Sodium Lactate to reverse drug-induced arrhythmias
- Pressor sympathomimetics to reverse drug-induced hypotension if indicated
for refractory arrhythmias
Class 1C
DOC for ventricular arrhythmias post-myocardial infarction
CLASS 1B: LIDOCAINE [B], MEXILETINE [C], TOCAINIDE [C], PHENYTOIN [D]
Group 1A
prolong the AP duration
“QPD”
QUINIDINE
PROCAINAMIDE
DISOPYRAMIDE
DRUGS USED FOR CARDIAC ARRHYTHMIA
contraindicated in post MI arrhythmias
Class IC
most effective since it can do all MOA of class 1 to 4.
Amiodarone
However, it is also the most toxic and has the most numerous side effects.
used antiarrhythmics for wolf parkinson white
Procainamide and Amiodarone
Sotalol and Amiodarone also have group____ effects
2
CLASS 2 MOA
Beta-adrenoceptor blockers
beta-blocker anti-arrhythmic that has Class 3 properties
Sotalol
CLASS 3 ANTIARRHYTHMICS act on what phase of the cardiac AP?
Phase 3
DOC FOR Digoxin-induced arrhythmias
CLASS 1B: LIDOCAINE [B], MEXILETINE [C], TOCAINIDE [C], PHENYTOIN [D]
Class 3
“VAIDDS”
VERNAKALANT
AMIODARONE
IBUTILIDE
DOFETILIDE
DRONEDARONE
SOTALOL
Why are dihydropyridine calcium channel blockers not useful as antiarrhythmics?
- dihydropyridine CCBs evoke compensatory sympathetic discharge which facilitates arrhythmias rather than terminating them.
- dihydropyridine CCBs can cause reflex tachycardia and are pro-arrhythmogenic.
Goup 1B
Shorten the AP duration
“LiMeToP”
LIDOCAINE
PHENYTOIN
TOCAINIDE
MEXILETINE
most arrhythmogenic among the class1 anti-arrhythmics that’s why they’re only used for refractory arrhythmias
Class 1C
ECG morphology of Class 3
increase in QT interval
CLASS 4 MOA
Calcium channel blockers
AMIODARONE TOXICITY
Pulmonary fibrosis
Paresthesia
Tremors
Thyroid dysfunction
Corneal deposits
Skin deposits
