CNS DRUGS - GENERAL ANESTHETICS

Question 1

Genetic disorder of susceptible individuals upon exposure to volatile anesthetics and succinylcholine

Answer 1

MALIGNANT HYPERTHERMIA

Question 2

known to cause CORONARY STEAL SYNDROME, the preferential redistribution of blood from ischemic areas to non-ischemic areas,

Answer 2

ISOFLURANE

* ISO (I saw) you STEAL my heart! ISOFLURANE! CORONARY STEAL SYNDROME!!!

Question 3

causes Renal insufficiency (due to Compound A formation)

Answer 3

SEVOFLURANE *yung V baliktarin mo, mukhang A. compound A!! Renal insufficiency!

Question 4

ALL inhaled anesthetics have BRONCHODILATING properties except

Answer 4

DESFLURANE (and ISOFLURANE to a lesser extent) – can cause airway irritability and hence is unsuitable for induction

Question 5

produces the MOST carbon monoxide out of all the inhaled anesthetics

Answer 5

Desflurane

Question 6

Lowest potency (highest MAC) and least cardiotoxic among inhalational anesthetics

Answer 6

Nitrous oxide

Question 7

Mnemonic for IV Anesthetics lifted from USMLE: the mighty King Proposes to Oprah:

Answer 7

Thiopental Midazolam, Ketamine, Propofol and Opioids

Question 8

most reliable test to establish susceptibility to malignant hyperthermia

Answer 8

Caffeine-Halothane contracture test

Question 9

“Milk of Amnesia”

Answer 9

PROPOFOL

Question 10

Described as sweet smelling

Answer 10

SEVOFLURANE

Question 11

antidote to Opioid analgesic (Fentanyl, morphine)

Answer 11

NALOXONE(DOC) / NALTREXONE

Question 12

treatment of MALIGNANT HYPERTHERMIA

Answer 12

DANTROLENE

Question 13

inhaled anes that can cause HEPATITIS

Answer 13

Halothane Hepatitis (immune mediated response characterized by eosinophilia)

Question 14

used for DISSOCIATIVE ANESTHESIA (analgesia, amnesia and catatonia but with retained consciousness)

Answer 14

KETAMINE

Question 15

causes EMERGENCE DELIRIUM

Answer 15

KETAMINE

Question 16

IV anes that causes ADRENOCORTICAL SUPPRESSION

Answer 16

ETOMIDATE

Question 17

unique amongst all inhaled anesthetics in that it requires a vaporizer because special heated and at normal room pressurized temperature, it would boil

Answer 17

DESFLURANE

Question 18

IV anesthetic induction of choice

Answer 18

PROPOFOL

Question 19

the lower the blood:gas partition coefficient, the ____ the rate of induction and recovery

Answer 19

the lower the blood:gas partition coefficient, the HIGHER the rate of induction and recovery

Question 20

Inhaled anes contraindicated for patients with asthma and hyperreactive airways

Answer 20

DESFLURANE

Question 21

Dissociative anesthesia seen in ketamine is characterized by ______ apparent in EEG

Answer 21

thalamocortical dissociation

Question 22

inhaled anesthetic with lowest partition coefficient

Answer 22

nitrous oxide

Question 23

inhaled anesthetic that has the highest MAC

Answer 23

Nitrous oxide

Question 24

only inhaled anesthetic that INCREASES cerebral blood flow and hence INCREASE ICP due to activation of sympathetic nervous system

Answer 24

Nitrous oxide

Question 25

inhaled anesthetic with highest partition coefficient

Answer 25

methoxyflurane

Question 26

inhaled anesthetic that has the lowest MAC

Answer 26

Methoxyflurane