ANTIBIOTICS - ANTIVIRAL

Question 1

DRUGS USED FOR HERPES

Answer 1

ACYCLOVIR

VALACYCLOVIR, PENCICLOVIR, DOCOSANOL, TRIFLURIDINE, FAMCICLOVIR

Question 2

anti- CMV drug

Answer 2

GANCICLOVIR, VALGANCICLOVIR

Question 3

used for CMV retinitis, Mucocutaneous HSV infections, Acyclovir-resistance, Ganciclovir-resistance, Genital warts, Molluscum contagiosum

Answer 3

CIDOFOVIR

Question 4

MOA: Activated by viral thymidine kinase (TK) to forms that inhibit viral DNA polymerase

Answer 4

ACYCLOVIR

Question 6

used for CMV retinitis, Acyclovir-resistance, HSV infection in patients with AIDS

Answer 6

FOSCARNET

Question 7

usual composition of HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART)

Answer 7

usually 2 NRTIs plus 1 protease inhibitor

Question 8

examples of Nucleoside Reverse Transcriptase Inhibitor (NRTI)

Answer 8

ZIDOVUDINE

ABACAVIR, DIDANOSINE, EMTRICITABINE, LAMIVUDINE, STAVUDINE, TENOFOVIR, ZALCITABINE

Question 9

used for prevention of maternal-fetal HIV transmission

Answer 9

Zidovudine (NRTIs)

Question 10

give examples of Non-nucleoside Reverse Transcriptase Inhibitor (NNRTI)

Answer 10

DELAVIRDINE

EFAVIRENZ, ETRAVIRINE, NEVIRAPINE, RILPIVIRINE

Question 11

NRTIs safe for pregnant

Answer 11

Lamivudine, Abacavir, Tenofovir, Emtricitabine

Question 12

does not need phosphorylation hence no BM suppression

Answer 12

NNRTIs and Foscarnet

Question 13

examples of PROTEASE INHIBITOR

Answer 13

INDINAVIR

AMPRENAVIR, ATAZANAVIR, DARUNAVIR, INDINAVIR, LOPINAVIR, NELFINAVIR, RITONAVIR, SAQUINAVIR, TIPRANAVIR, FOSAMPRENAVIR, BOCEPREVIR, TELAPRIVIR

Question 14

Binds to gp41 subunit of viral envelope glycoprotein, preventing fusion of viral and cellular membranes; INHIBITS VIRAL ENTRY

Answer 14

ENFUVIRTIDE

Question 15

Blocks viral attachment via transmembrane chemokine receptor CCR5

Answer 15

MARAVIROC

Question 16

NRTI or NNRTI?

(+) phosphorylation

(-) DNA Polymerase

competitive inhibitor

SE: peripheral neuropathy, fatal syndrome of lactic acidosis, fatal hypersensitivity syndrome

Answer 16

NRTIs

Question 17

NRTI or NNRTI?

(-) phosphorylation

does not (-) DNA Polymerase

non - competitive inhibitor

SE: rash

more drug interactions and side effects

(+) metabolism and induction of CYP 450

Answer 17

NNRTI

Question 18

MOA: Inhibit early step replication and prevent uncoating by binding to M₂ proton channels

Answer 18

AMANTADINE

RIMANTADINE

Question 19

Amantadin is used for ______

Answer 19

Influenza A only

Question 20

Inhibits Neuraminidase. Decreases release of progeny virus. Anti influenza

Answer 20

OSELTAMIVIR

ZANAMIVIR, PERAMIVIR

Question 21

Presently the drugs of choice for influenza (including H1N1)

Answer 21

OSELTAMIVIR

Question 22

inhibits viral penetration, uncoating,mRNA synthesis, translation, assembly and release

Answer 22

INTERFERON

Question 23

used in HBV infection, HCV infection, Kaposi sarcoma, Genital warts

Answer 23

Interferon

Question 24

Inhibits HBV DNA polymerase

Answer 24

LAMIVUDINE

ADEFOVIR DIPIVOXIL, ENTECAVIR, TELBIVUDINE, TENOFOVIR, CLEVUDINE

Question 25

Inhibits guanosine triphosphate formation. Prevents capping of viral mRNA. Blocks RNA-dependent RNA polymerases. “Lethal Mutagenesis”

Answer 25

Ribavirin