CNS DRUGS - ANTIDEPRESSANTS Flashcards
TRICYCLIC ANTIDEPRESSANTS (TCA)
IMIPRAMINE [D]
CLOMIPRAMINE [C], DESIPRAMINE [C], AMITRYPTYLINE [C], NORTRYPTILINE [D], DOXEPIN, PROTRIPTYLINE [C], TRIMIPRAMINE [C]
FIRST LINE agen for Major depressive disorder not responsive to SSRI
IMIPRAMINE [D]
(TCAs)
3Cs of TCA overdose
Coma, Cardiotoxicity, Convulsions
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI)
FLUOXETINE [C]
PAROXETINE [D], CITALOPRAM [C], ESCITALOPRAM [C], SERTRALINE [C], FLUVOXAMINE [C], VILAZODONE
DOC for Major Depressive Disorder
SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI)
FLUOXETINE [C], PAROXETINE [D], CITALOPRAM [C], ESCITALOPRAM [C], SERTRALINE [C], FLUVOXAMINE [C], VILAZODONE
class of drugs with high risk of serotonin syndrome if co-administered with MAOi
SSRI
SSRI which has been developed for treatment of Premature Ejaculation taken 1-3 hours prior to coitus
DAPOXETINE
What drugs can cause erectile dysfunction?
Mnemonic: A SORE PeniS can’t Fuck Hard!
SSRIs
Opiates
Risperidone
Ethanol, Estrogen
Propranolol
Spironolactone
Finasteride
Hydrochlorothiazide
life-threatening syndrome characterized by severe muscle rigidity, myoclonus, hyperthermia, cardiovascular instability, and marked CNS stimulatory effects, including seizures
Serotonin Syndrome
What are the features of Serotonin Syndrome?
“FAT CHD”
Fever
Agitation
Tremor
Clonus
Hyperreflexia
Diaphoresis
SELECTIVE SEROTONIN NOREPINEPHRINE REUPTAKE INHIBITOR (SNRI)
VENLAFAXINE [C]
DULOXETINE
MILNACIPRAN
DESVENLAFAXINE
Increased risk for suicide in children and adolescents
SNRIs
SEROTONIN ANTAGONIST
TRAZODONE [C]
NEFAZODONE [C], VORTIOXETINE
What drugs can cause PRIAPISM?
“Tigas PeniS Qo, AyaW Bumaba!”
Trazodone
Papaverine
Sildenafil
Quetiapine
Alprostadil
Warfarin
Bupropion
TETRACYCLIC ANTIDEPRESSANTS
MOA: Strong norepinephrine reuptake inhibitor and weak serotonin reuptake inhibitor. Blocks dopamine D 2 receptors. Resembles TCA in terms of effects
AMOXAPINE [C]
MAPROTILINE [B]
TETRACYCLIC ANTIDEPRESSANTS
MOA: Increases amine release from nerve endings by antagonism of presynaptic a 2 adrenoceptors. Blocks serotonin 5HT 2 receptors.
MIRTAZAPINE [C]
(Unicyclic aminoketone)
MOA: nhibits neuronal reuptake of dopamine and NE. increases dopamine and NE activity.
BUPROPION [C]
antidepressants that are not associated with sexual
dysfunction as side effect
Mirtazapine, Bupropion and Nefazodone
MAO INHIBITORS
PHENELZINE [C]
TRANYLCYPROMINE
SELEGILINE
ISOCARBOXAZID
give examples of tyramine rich food
avocado, Cheese, wine
releasers of norepinephrine from the presynaptic vesicles
“release the TAE”
release the TAE: Tyramine, Amphetamine and Ephedrine
precipitating drugs for Serotonin Syndrome
SSRIs, MAOIs, TCAs, Meperidine, MDMA, St. John’s Wort
Precipitating drug for Neuroleptic Malignant syndrome
ANTIPSYCHOTICS
mechanism of NEUROLEPTIC MALIGNANT SYNDROME
Dopamine antagonism
first line of treatment for NEUROLEPTIC MALIGNANT SYNDROME
Diphenhydramine
