CNS DRUGS - ANTIDEPRESSANTS

Question 1

TRICYCLIC ANTIDEPRESSANTS (TCA)

Answer 1

IMIPRAMINE [D]

CLOMIPRAMINE [C], DESIPRAMINE [C], AMITRYPTYLINE [C], NORTRYPTILINE [D], DOXEPIN, PROTRIPTYLINE [C], TRIMIPRAMINE [C]

Question 2

FIRST LINE agen for Major depressive disorder not responsive to SSRI

Answer 2

IMIPRAMINE [D]

(TCAs)

Question 3

3Cs of TCA overdose

Answer 3

Coma, Cardiotoxicity, Convulsions

Question 4

SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRI)

Answer 4

FLUOXETINE [C]

PAROXETINE [D], CITALOPRAM [C], ESCITALOPRAM [C], SERTRALINE [C], FLUVOXAMINE [C], VILAZODONE

Question 5

DOC for Major Depressive Disorder

Answer 5

SELECTIVE SEROTONIN REUPTAKE INHIBITOR (SSRI)

FLUOXETINE [C], PAROXETINE [D], CITALOPRAM [C], ESCITALOPRAM [C], SERTRALINE [C], FLUVOXAMINE [C], VILAZODONE

Question 6

class of drugs with high risk of serotonin syndrome if co-administered with MAOi

Answer 6

SSRI

Question 7

SSRI which has been developed for treatment of Premature Ejaculation taken 1-3 hours prior to coitus

Answer 7

DAPOXETINE

Question 8

What drugs can cause erectile dysfunction?

Mnemonic: A SORE PeniS can’t Fuck Hard!

Answer 8

SSRIs

Opiates

Risperidone

Ethanol, Estrogen

Propranolol

Spironolactone

Finasteride

Hydrochlorothiazide

Question 10

life-threatening syndrome characterized by severe muscle rigidity, myoclonus, hyperthermia, cardiovascular instability, and marked CNS stimulatory effects, including seizures

Answer 10

Serotonin Syndrome

Question 11

What are the features of Serotonin Syndrome?

“FAT CHD”

Answer 11

Fever

Agitation

Tremor

Clonus

Hyperreflexia

Diaphoresis

Question 12

SELECTIVE SEROTONIN NOREPINEPHRINE REUPTAKE INHIBITOR (SNRI)

Answer 12

VENLAFAXINE [C]

DULOXETINE

MILNACIPRAN

DESVENLAFAXINE

Question 13

Increased risk for suicide in children and adolescents

Answer 13

SNRIs

Question 14

SEROTONIN ANTAGONIST

Answer 14

TRAZODONE [C]

NEFAZODONE [C], VORTIOXETINE

Question 15

What drugs can cause PRIAPISM?

“Tigas PeniS Qo, AyaW Bumaba!”

Answer 15

Trazodone

Papaverine

Sildenafil

Quetiapine

Alprostadil

Warfarin

Bupropion

Question 17

TETRACYCLIC ANTIDEPRESSANTS

MOA: Strong norepinephrine reuptake inhibitor and weak serotonin reuptake inhibitor. Blocks dopamine D 2 receptors. Resembles TCA in terms of effects

Answer 17

AMOXAPINE [C]

MAPROTILINE [B]

Question 18

TETRACYCLIC ANTIDEPRESSANTS

MOA: Increases amine release from nerve endings by antagonism of presynaptic a 2 adrenoceptors. Blocks serotonin 5HT 2 receptors.

Answer 18

MIRTAZAPINE [C]

Question 19

(Unicyclic aminoketone)

MOA: nhibits neuronal reuptake of dopamine and NE. increases dopamine and NE activity.

Answer 19

BUPROPION [C]

Question 20

antidepressants that are not associated with sexual

dysfunction as side effect

Answer 20

Mirtazapine, Bupropion and Nefazodone

Question 21

MAO INHIBITORS

Answer 21

PHENELZINE [C]

TRANYLCYPROMINE

SELEGILINE

ISOCARBOXAZID

Question 22

give examples of tyramine rich food

Answer 22

avocado, Cheese, wine

Question 23

releasers of norepinephrine from the presynaptic vesicles

“release the TAE”

Answer 23

release the TAE: Tyramine, Amphetamine and Ephedrine

Question 24

precipitating drugs for Serotonin Syndrome

Answer 24

SSRIs, MAOIs, TCAs, Meperidine, MDMA, St. John’s Wort

Question 25

Precipitating drug for Neuroleptic Malignant syndrome

Answer 25

ANTIPSYCHOTICS

Question 26

mechanism of NEUROLEPTIC MALIGNANT SYNDROME

Answer 26

Dopamine antagonism

Question 27

first line of treatment for NEUROLEPTIC MALIGNANT SYNDROME

Answer 27

Diphenhydramine