ANTIBIOTICS - ANTIHELMINTHICS

Question 1

DOC for Strongyloides

Answer 1

Ivermectin

Question 2

DOC for Enterobius

Answer 2

Pyrantel pamoate / metronidazole

Question 3

DOC for filariasis

Answer 3

Diethycarbamazine (DEC)

Question 4

MOA of albendazole

Answer 4

Inhibits microtubule assembly. Larvicidal and ovicidal.

Question 5

Uses of albendazole

Answer 5

Ascariasis, Hookworm, Pinworm, Hydatid disease (drug of choice), Whipworm infections, Cutaneous & Visceral Larva migrans, Cysticercosis (larval stages of T. solium), Angiostrongylus cantonensis, Capillaria philippinensis

Question 6

MOA of Mebendazole

Answer 6

Selectively inhibits microtubule synthesis and glucose uptake in nematodes. Ovicidal.

Question 7

DOC for Whipworms

Answer 7

MEBENDAZOLE

Question 8

DOC of Trichinosis

Answer 8

THIABENDAZOLE

Question 9

MOA of DEC

Answer 9

Immobilizes microfilariae (by an unknown mechanism) and alters their surface structure → more susceptible to host defense mechanisms

Question 10

DOC of Eye worm disease (Loa Loa)

Answer 10

DEC

Question 11

MOA of Ivermectin

Answer 11

Intensifies GABA-mediated neurotransmission nematodes. Immobilizes parasites.

Question 12

DOC for Fasciola hepatica

Answer 12

Bithionol or triclabendazole

Question 13

DOC for Schistosoma

Answer 13

Praziquantel

Question 14

DOC for cysticercosis and echinococcus granulosus

Answer 14

ALbendazole

Question 15

DOC for tapeworms except Cysticercosis and hydatid disease

Answer 15

praziquantel

Question 16

MOA of PRAZIQUANTEL

Answer 16

Increases membrane permeability to calcium → paralysis. Causes muscle paralysis, vacuolization and death.

Question 17

Alternative drug for cestode infections (Taenia, Diphyllobothrium, Hymenolepsis, Dipylidium, Fasciolopsis, Heterophyes)

Answer 17

NICLOSAMIDE