Ibuprofen feb 24 2022

Question 1

What is Ibuprofen commonly used to treat?

Answer 1

Fever, pain, dysmenorrhea (painful menstrual cramps), arthritis

Also referred to as Advil, Ibuprofen is a common over-the-counter medication.

Question 2

What classification does Ibuprofen fall under?

Answer 2

Nonsteroidal anti-inflammatory (NSAID) , analgesic, nonopioid drug

It is commonly used for its pain-relieving and anti-inflammatory properties.

Question 3

What is the mechanism of action of Ibuprofen?

Answer 3

Reversibly inhibits cyclooxygenase-1 and 2 (COX-1 and 2) enzymes

This leads to decreased formation of prostaglandin precursors.

Question 4

What properties does Ibuprofen have?

Answer 4

Antipyretic, analgesic, anti-inflammatory

These properties make it effective in treating various conditions.

Question 5

What is the onset of action for Ibuprofen when taken orally for analgesic effects?

Answer 5

30-60 minutes

Maximum effect for antipyretic properties is 2-4 hours.

Question 6

What is the typical half-life elimination of Ibuprofen?

Answer 6

Around 2 hours

Question 7

What advantages does Ibuprofen have over other NSAIDs?

Answer 7

Good relief for dysmenorrhea, promotes closure of ductus arteriosus in pre-term infants, well tolerated

It has less adverse effects and lower association with gastric bleed compared to Aspirin.

Question 8

What are the indications for using Ibuprofen?

Answer 8

Fever, mild to moderate pain, dysmenorrhea, arthritis

Question 9

What are the contraindications for Ibuprofen?

Answer 9

Hypersensitivity to Ibuprofen or NSAIDs, active GI bleed, pregnant patients in 3rd trimester

Asthmatic patients sensitive to NSAIDs or Aspirin should also avoid it.

Question 10

What CNS adverse reactions can occur with Ibuprofen?

Answer 10

Dizziness, fatigue, headache, nervousness

Question 11

What CVS adverse reactions can occur with Ibuprofen?

Answer 11

Increased fluid retention, edema (rare)

Question 12

What is the adult dosing for mild to moderate pain with Ibuprofen?

Answer 12

400 mg PO every 4-6 hours prn

Question 13

What is the adult dosing for primary dysmenorrhea with Ibuprofen?

Answer 13

400 mg PO every 4 hours prn

Question 14

What is the adult dosing range for arthritis with Ibuprofen?

Answer 14

500 mg to 3.2 g/day every 4 hours prn

Question 15

What is the pediatric dosing for fever reduction in patients with a temperature up to 39?

Answer 15

5 mg/kg PO every 6-8 hours

Question 16

What is the pediatric dosing for fever reduction in patients with a temperature greater than 39?

Answer 16

10 mg/kg PO every 6-8 hours

Question 17

What is the pediatric dosing for juvenile arthritis?

Answer 17

30-40 mg/kg/day PO in 3 to 4 divided doses