HMG Coenzyme A Statins: Atorvastatin (Lipitor), Fluvastatin (Lescol), Lovastatin (Mevacor), Pravastatin (Pravachol), Rosuvastatin (Crestor), Simvastatin (Zocor) ACS Medication

Question 1

Classification:

Answer 1

• HMG-CoA reductase inhibitors (Statins)

Question 2

Action:

Answer 2

• Reduces the level of circulating total cholesterol low density lipoprotein cholesterol, and serum triglycerides
• Reduces the incidence of reinfarction, recurrent angina, rehospitalization, and stroke when initiated within a fe days after onset of ACS

Question 3

Indications:

Answer 3

• ACS/AMI prophylaxis
• Hypercholesterolemia
• Hyperlipoproteinemia
• Hypertriglyceridemia
• Stroke prophylaxis

Question 4

Adverse Effects:

Answer 4

• Constipation
• Flatulence
• Dyspepsia
• ABD pain
• Infection
• Headache
• Flu like symptoms
• Back pain
• Allergic reaction
• Asthenia
• Diarrhea
• Sinusitis
• Pharyngitis
• Rash
• Arthralgia
• Nausea/vomiting
• Myopathy
• Myasthenia
• Renal failure
• Rhabdomyolysis
• Chest pain
• Bronchitis
• Rhinitis
• Insomnia

Question 5

Contraindications:

Answer 5

• Active hepatic disease
• Pregnancy
• Breastfeeding
• Rhabdomyolysis

Question 6

Dosage (Adult):

Answer 6

• Medication is administered PO. Dosage is individualized

Question 7

Dosage (Pediatric):

Answer 7

• Safe use not established