Atropine Sulfate Flashcards
1
Q
Classification:
A
- Anticholinergic (Antimuscarinic)
2
Q
Action:
A
- Competes reversibly w/ acetylcholine at site of the muscarinic receptor. Receptors affected, in order from the most sensitive to the least sensitive, include salivary, bronchial, sweat glands, eye, heart and GI tract
3
Q
Indications:
A
- Symptomatic bradycardia
- Asystole/ PEA
- Nerve agent exposure
- Organophosphate poisoning
4
Q
Adverse Effects:
A
- Decreased secretions resulting in dry mouth and hot skin temp
- Intense facial flushing
- Blurred vision/ dilation of the pupils w/ subsequent photophobia
- Tachycardia
- Restlessness
- May cause paradoxical bradycardia if dose administered is too low/ if the drug is administered too slowly
5
Q
Contraindications:
A
- Acute MI
- Myasthenia gravis
- GI obstruction
- Closed angle glaucoma
- Known sensitivity to atropine, belladonna alkaloids, sulfites
- Will not be effective for infranodal AV block and new third degree block w/ wide QRS complex
6
Q
Symptomatic Bradycardia Dosage (Adult):
A
- 0.5 mg IV, IO every 3-5 mins to max dose of 3 mg
7
Q
Symptomatic Bradycardia Dosage (Adolescent):
A
- 0.02 mg/kg (minimum 0.1 mg/dose; max 0.5 mg/dose) IV, IO to total dose of 1 mg
8
Q
Symptomatic Bradycardia Dosage (Pediatric):
A
- 0.02 mg/kg (minimum 0.1 mg/dose; max 0.5 mg/dose) IV, IO to total dose of 1 mg
9
Q
Nerve Agent/ Organophosphate Poisoning Dosage (Adult):
A
- 1 to 6 mg IV, IM; Repeat if needed every 5 mins until symptoms dissipate
10
Q
Nerve Agent/ Organophosphate Poisoning Dosage (Pediatric):
A
- 0.05 mg/kg IV, IM every 10-30 mins as needed until symptoms dissipate
11
Q
Nerve Agent/ Organophosphate Poisoning Dosage (Infants less than 15 pounds):
A
- 0.05 mg/kg IV, IM every 5-20 mins as needed until symptoms dissipate
12
Q
Special Considerations:
A
- Severe organophosphate exposures may require massive amounts of atropine, well beyond what is carried in most EMS vehicles
- Half life is 2.5 hours
