Fibrinolytic: Tissue Plasminogen Activator (TPA) ACS Medication

Question 1

Classification:

Answer 1

• Thrombolytic agent

Question 2

Action:

Answer 2

• Dissolves thrombi plugs in the coronary arteries and reestablishes blood flow

Question 3

Indications:

Answer 3

• ST segment elevation (Greater than 1 mm in two or more contiguous leads)
• New or presumed new left bundle branch block

Question 4

Adverse Effects:

Answer 4

• Bleeding
• Intracranial hemorrhage
• Stroke
• Cardiac arrhythmias
• Hypotension
• Bruising

Question 5

Contraindications:

Answer 5

• ST segment depression
• Cardiogenic shock
• Recent (Within 10 days) major surgery
• Cerebrovascular disease
• Recent (Within 10 days) GI bleeding
• Recent trauma
• Severe HTN (Systolic greater than 180, diastolic greater than 110)
• High likelihood of left heart thrombus
• Acute pericarditis
• Subacute bacterial endocarditis
• Severe renal or liver failure w/ bleeding complications
• Significant liver dysfunction
• Diabetic hemorrhagic retinopathy
• Septic thrombophlebitis
• Advanced age (Older than 75 years)
• Pts taking warfarin (Coumadin)

Question 6

Dosage:

Answer 6

• Dosing per medical direction