Eptifibatide (Integrilin) ACS Medication

Question 1

Classification:

Answer 1

• GP IIb/IIIa inhibitor

Question 2

Action:

Answer 2

• Prevents aggregation of platelets by binding to the GP IIb/IIIa receptor

Question 3

Indications:

Answer 3

• UA/NSTEMI
• To manage medically and for those undergoing percutaneous coronary intervention

Question 4

Adverse Effects:

Answer 4

• Bleeding from GI tract
• Internal bleeding
• Intracranial hemorrhage
• Hypotension
• Stroke
• Anaphylactic Shock

Question 5

Contraindications:

Answer 5

• Bleeding from any source
• Severe uncontrolled HTN
• Surgery/ trauma within previous 6 weeks
• Stroke within previous 30 days
• Renal failure
• Thrombocytopenia

Question 6

Dosage (Adult):

Answer 6

• Loading dose: 180 mcg/kg IV, IO (Max dose: 22.6 mg) over 1-2 mins,
• Then 2 mcg/kg/min IV, IO infusion (Max dose: 15 mg/hr)

Question 7

Dosage (Pediatric):

Answer 7

• No current dosing recommendations exist for pediatric Pts

Question 8

Special Considerations:

Answer 8

• Half life approximately 90-150 mins