Dobutamine (Dobutrex)

Question 1

Classification:

Answer 1

• Adrenergic agent
• Inotropic

Question 2

Action:

Answer 2

• Acts primarily as an agonist beta 1 adrenergic receptors w/ minor beta2 and alpha1 effects
• Dobutamine increases myocardial contractility and stroke volume w/ minor chronotropic effects, resulting in increased cardiac output

Question 3

Indications:

Answer 3

• CHF
• Cardiogenic shock

Question 4

Adverse Effects:

Answer 4

• Tachycardia
• PVCs
• HTN
• Hypotension
• Palpitations
• Arrhythmias

Question 5

Contraindications:

Answer 5

• Suspected/ known poisoning/ drug induced shock
• Systolic BP less than 100 mm Hg w/ signs of shock
• Idiopathic hypertrophic subaortic stenosis
• Known sensitivity (Including sulfites)
• Use w/ caution in HTN, recent MI, arrhythmias, hypovolemia

Question 6

Dosage (Adult):

Answer 6

• Initial 0.5 to 1 mcg/kg/min IV, IO. Maintenance infusions are typically 2-20 mcg/kg/min
• Doses greater than 20 mcg/kg/min, increases HR of greater than 10% may induce or exacerbate myocardial ischemia

Question 7

Special Considerations:

Answer 7

• Half life 2 minutes