histo heart vessels Flashcards
endocardium
- endothelium: simple sq. epith
- subendothelial ct: fine + tight collagen fibers og f.blasts
3.middle layer: elastic fibers, collagen, f.blast og SMOOTH MUSCLE - subendocardial layer: collagen, elastic f, f.blast.
og loose CT og adipose tissue með vessels and nerves
Epicardium
- simple sq mesothelium
- fibroelastic CT
- adipose tissue, with coronary vessels og nerves
cardiac skeleton
of dense ct
- 4 fibrous rings around base of aorta, pulm artery and both av orifices
- 2 fibr. trigones.. right one er ct bridge milli aortic valve and right av valve rings. Left one milli aortic valve og left av valve rings
- av bundle/hiss thru right fibr. trigone
- c. skeleton a milli atria og ventricles. At surf of heart is projected to coronary sulcus
heart valves and fibr. rings
heart valve core of ct, cov w endothelium, cont with endoth of the chambers
-they are duplicatures of endocardium inserted to fibr rings.
Arteries
- large or elastic
- medium or muscular
- small arteries or arterioles
Large(elastic) arteries
- tunica intima: simple endothelium, w supporting basement membrane with elastin rich collagen
- tunica media: very broad, with elastic fibers og collagen, few smooth m fibers
- tunica adventitia: various amount of collagen and elastin. Quite dense CT but changes to loose CT near periphery. HAS VASA VASORUM (large arteries need their own blood supply)
-Internal elastic lamina: layer of elastic tissue forming outermost part of tunica intima. (seperating tunica intima from tunica media)
it is a fenestrated elastic sheath, allows diffusion of nutrients to arterial wall
Medium (muscular) arteries
- tunica intima: endothelium
- tunica media: mest SMOOTH MUSCLE, en smá elastin og collagen
- tunica adventita: VERY BROAD. mest collagen og elastin
-the external elastic lamina milli tunica media og tunica adv. er reduced miðað við í elastic arteries.
Arterioles
- regulate blood flow into capillary beds
1. tunica intima: very thin endothelial layer mostly of collagen 3 and little elastin og gr. substance - fenestrated internal elastic lamina absent in small og terminal arterioles. Present in larger ones
2. tunica media: Small ones single layer smooth muscle cells. Larger ones 2 til 3 layers smooth muscle cells.*
3. tunica adventita: er scant, fibroelastic tissue, merges w surr. tissue
Capillary bed
arterioles give rise to metarterioles.
precapillary spinchter at junction of metarterioles and capillary regulate blood flow.
thoroughfare channel connects metarteriole to a venule. t.d intestine, liver, spleen
arteriovenous anastomosis er direct conn. milli small arteriole and small vein. t.d i skin
capillaries
terminal arterioles branch to form capillaries, sem conn. arterial and venous systems.
-single layer endothelium on thin basem. membrane of glycoprotein
Types of capillaries
- cont. capillaries: continous endothelium and cont. basal lamina. In muscle, lung, nervous tissue and exocrine glands
- fenestrated capillaries: with pores(fenestrea) with or without diaphragm.
-endoth. cells w fenestrae and cont. basal lamina.
In intestines and endocrine glands(w diaphragm)
In renal glomerolus(w.out diaphragm)
3.discontinous (sinusoids)
endoth. cells w gaps and discont. basal lamina
In liver, spleen, adrenal and pit. gland
Capillary functions
- semiperm. barrier
- nonthrombogenic surf
- prostaglandins, serotonin (deactivates them)
- catabolize lipoproteins into triglyc. and fatty acids
- convert angiotensin 1 to angiotensin 2
- release prostacyclins to inhibit aggregation of platelets
- promote fibrinolysis(prod. activators of plasminogens)
- binding sites for some clotting factors
- release tissue factors to initiate clotting response
Pericytes
vascular wall cells in basem. membr of microvessels (direct physical contact + paracrine signal)
-extend processes along capillaries, precapillary arterioles and postcapillary venules
-CNS pericytes uniquely staðsett in neurovascular unit between endoth. cells, astrocytes and neurons
function:
a. skel. muscle regeneration and fat formation
b. angiogenesis and survival of endoth. cells
c. blood brain barrier
d. blood flow.
veins
- small veins or venules
- medium veins
- large veins
sömu 3 lög.
tunica adventita er stærsta lagið
valves
lymp. vessels
thin walled, w valves
- endoth
- smooth muscle
- adventita binds them to surr. tissues
- absorption of interstital fluid from tissues
- lymph flows to larges lymph vessel in body thoracic duct and then to right/left subclavian veins