fungal diseases Flashcards
Aspergillosis
A. fumigates, A.flavus
most aspergillum species do
not cause disease
route of infection for Aspergillosis
inhalation of spore
-‘sick building syndrome’
aspergillosis can range from
an allergy to disseminated aspergillosis
disseminated Aspergillosis
60-90% mortality
most dangerous diseases caused by aspergillosis are due to
opportunistic pathogens- immunosuppressed patients
cryptococcosis causative agents
cryptococcus neofromans and cryptoccus gattiic
route of infection for cryptococcosis
inhalation, sexual cycle produces small spores
what disease can Cryptoccosis cause
Pulmonary cryptococcosis and meningitis
pulmonary cryptococcosis
asymptomatic and chronic- can become intracellular pathogen and persist
cryptococcosis meningitis
can occur in normal individuals, but especially in AIDs patients. 30% mortality
cryptococcis is an
opportunistic/ primary pathogen
pneumocystis
caused by Pneumocystis jirovecii
diseases caused by Pneumocystis
pneumonia- dry cough/ shortness of breath
pneumocystis more common in
immunocompromised patients
mortality of Pneumocystis
5-40%
route of infection for pneumocystis
inhalation
Pneumocystis jirovecii
non cultural in vitro
genome sequence of Pneumocystis
lacks genes for amino acid biosynthesis- scavenges amino acids from the host
