FREE LIVING PATHOGENIC AMOEBA OF MAN Flashcards
are facultative parasites of
man.
Acanthamoeba and naegleria
Acanthamoeba inhibatis what in the human body
central nervous system
Trophozoite can assume limax form or become
ameboflagellate
NAEGLERIA FOWLERI
Has both amoeba and flagellated form
N.fowleri
Ameboid: has a blunt pseudopodia and a vesicular
nucleus with a large karyosome and sparse
granules of peripheral chromatin
N.fowleri
Only amoeboid trophozoite inside the
host
N.fowleri
Flagellated: elongated and bears two equal and
anteriorly located flagella
N.fowleri
Elongated with 2 flagella
N.fowleri
when inside the host, they do not exhibit the flagellated stage and
cysts are not also formed; only the ameboid form is
present inside the host
Naegleria trophozoites
Cyst wall is smooth and double, with the outer wall
perforated by 3 – 8 pores (ostioles)
N.fowleri
single nucleus
N.fowleri cyst
Spherical chromatoid bodies
N.fowleri cyst
N.fowleri can survie in what temp
46 deg cel
N.fowleri can survive in what measurement of chlorinated waterPri
0.5 ug/mL
N.fowleri is the major causative agent of what disease?
Primary Amebic
Meningoencephalitis (PAM)
Causes purulent spinal fluid with motile amoeba
N.fowleri
“brain eating amoeba”
N.fowleri
portal of enrty of acanthamoeba spp?
broken or ulcerated skin or eye, lungs, genitourinary tract
(GUT)
disease of contanct lens wearers
ulcerative Acanthamoeba keratitis
Characterized by severe ocular p
ulcerative acanthamoeba keratitis
Lesions in the brain
○ Chronic central nervous system infection;
generally, in debilitated or immunocompromised
patients
Granulomatous Amebic Encephalitis (GAE)
laboratory diagnosis of acanthamoeba spp
Cerebrospinal fluid
nasal swabs
PYGC medium containing antibiotics
