FINAL GHM LECTURE

Question 1

Describe the classification of endocrinopathies

Answer 1

Primary - Problem with downstream glands
Secondary - Problem with pituitary
Tertiary - Problem with hypothalamus
Other - Damage to receptor mechanism in target tissue

Question 2

Describe the causes, symptoms and treatment of panhypothyrodism

Answer 2

Decrease in production of all pituitary hormones (TSH, stimulates thyroid gland), therefore, deficiency in T3 and T4.

Causes:
1. Tumours: pituitary adenomas, tumours near pituitary gland, compress infundibular stalk

2. Infections: meningites, inflammation + damage to pituitary gland - autoimmune
3. Vascular disease: pituitary apoplexy - sudden loss of blood supply to pituitary gland, due to pituitary tumour. Sheehan syndrome: pituitary gland ischaemia - lack of blood supply
4. Congenital hypoplasia: undeveloped pituitary gland from borth
5. Surgery, radiation

Deficiency in

ACTH: Less cortisol therefore, Hypoglucemia

TSH: less thyroxine = fatigue, bradycardia, constpiation

LH, FSH: Less testosterone, oestrogen - delayed puberrty, micopenis, lack of male muscle, amenorrhoea

Growth Hormone: Dwarfism