Final Exam: The Immune System and Cancer

Question 1

The idea that many tumors never fully mature into life-threatening cancers because of immune-mediated destruction of nascent malignancies

Answer 1

immune surveillance

Question 2

What two things do cancer cells produce?

Answer 2

1. different protiens (antigens)

2. Oncogenes

Question 3

3 major cell types that participate in tumor cell destruction:

Answer 3

1. T cell
2. Macrophage
3. NK cell

Question 4

What are the 3 approacdhes to tumor immunotherapy

Answer 4

1. nonspecific immune stimulation
2. passive immunization
3. active immunization

Question 5

cells, antibodies, immunoactivating cytokines, combination with chemotherapy and radiotherapy

Answer 5

immunotherapy

Question 6

4 important elements of tumor progression?

Answer 6

1. elevated WBC
2. Inc. WBC count as tumor progresses
3. Dec. in CD3 and CD4 cells
4. inc TGF-B

Question 7

What 5 cell types produce TGF-B during tumor formation?

Answer 7

1. T cells
2. B cells
3. Macrophages
4. Platelets
5. Neutrophils

Question 8

What 4 things does TGF-B do?

Answer 8

1. Regulates B cell functiob
2. Regulates macophages
3. regulates T cell actiation
4. Regulates other cells (growth, proliferation, etc.)