Exam 1: NK Cells Flashcards
Where do NK cells originate?
Bone marrow
Where are NK cells found?
blood, spleen, liver
T/F. NK cells posses receptors generated through gene segment rearrangement
F
What are the 3 categories of cell trafficking receptors on NK cells
- Chemotactic receptors
- Cytokine receptors
- Adhesion receptors
T/F. NK cells contain granules
T
2 roles of NK cells
- Kill stressed cells, infected cells and tumor cells
2. cytokine and chemokine production
How do NK cells recognize abnormal cells?
cell surface markers
What is expressed on the surface of all normal cells?
MHC I
What 4 things are often expressed on the surface of stressed cells?
- MICA
- MICB
- Rae-1
- H60
What are the 2 types of receptors expressed on NK cells?
- Activating
2. Inhibitory
A high level of activating receptors on the NK cell will lead to ____
killing of target
A strong inhibitory signal on the NK cell will lead to _____
preserves target cell
T/F. Normally on NK cells, inhibitory signals are blocked by activating signals
F. activating is blocked by inhibitory
What does NKG2d recognize?
stress proteins
What are the 2 effector functions of NK cells
- Lysis of infected, stressed, or transformed cells
2. Activation of macrophages through release of cytokines
What are the 3 NK cell cytotoxicity mechanisms
- Perforin-dependent mechanism
- CD95/CD95L mechaniam
- CD16 Killing pathway
T/F. Target recognition through CD16 will occur only when antibodies are present?
T
Treatment of NK cells with cytokines turns them into _____.
Lymphokine activated killer cells (LAK)
What cytokine is produced by NK cells and enhances macrophage pagocytic activity?
IFN-y
T/F. NKT cells develop into memory cells.
F.
What is the purpose of NKT cells
Link the T cell and NK cell systems
NKT cells are important for what 4 things:
- Allergies
- Antitumor immunity
- autoimmunity
- antimicrobial immunity
Dendritic cells that share some properties with NK cells
NK DCs
What is the purpose of NK DCs?
link the gap b/t innate and adaptive immunity
