Exam 2: Hypersensitivity type 2 and 3 Flashcards
Antibody response that occurs during blood transfusions?
Type II Hypersensitivity
What is the main antibody we find when blood matching?
IgM
What does IgM cause in blood transfusion reactions?
- agglutination
- opsonization
- phagocytosis
- hemolysis
What is HDN?
Hemolytic dz of the newborn
foal with diff blood type from mare. foal ingests antigens in colostrom from mother
What are the 2 types of hypersensitivity type
3 reactions?
local type
generalized type
What happens in local type, hypersens. type 3 rxn?
immune complexes are formed within tisssues
What happens in generalized type hypersensi. type 3 rxns?
immune complexes are formed within the blood stream. complexes are deposited in glomeruli in the kidney
red edematous swelling, local hemorrhage, thromosis, and tissue destructions is known as what rxn?
arthus rxn
What are 3 examples of type 3 hypersen. local type?
- blue eye
- hypersensitivity pneumonitis
- staphylococcal hypersensitivity
What is generalized type 3 hypersensitivity?
antigen ab. immune complex present in blood
how is the immune complex of generalized type 3 hypersen. usually eliminated from blood?
erythrocytes/ macrophages
What happens when the immune complex of type 3 hypersensitivity is not removed from blood?
accumulate and leave blood
head to kidneys and brain
What are 3 places effected by serum sickness
- joints
- kidney
- vessels
3 types of lesions seen in kidneys during mesangioproliferative glomerulonephritis
type 1, type 2, type 3
Which type of mesangiopro. glomerulonephritis effects mesangial and subendothelial regions
type 1
