Exam 2: Type 1 Hypersensitivity Flashcards
Type 1 hypersensitivity is an exaggerated Th1 or Th2 response?
Th2
What is an example of a type 1 hypersensitivity rxn?
allergies
Type 1 hypersensitvity is caracterized by an overproduction of Ig__
E
In type 1 hypersensitivity, IL-__ is overproduced and therefore increasing Th2 activation and b cell stimulation.
4
T/F FceRI binds irreversibly
T
What 6 cell types have FcERI receptors?
- Mast cells
- Basophils
- Neutrophils
- Eosinophils
- Macrophages
- Dendritic cells
What 6 cell types contain FcERII receptors?
- B cells
- NK cells
- Macrophages
- DCs
- Eosinophils
- Platelets
Where are mast cells located?
intestine, skin, airways, around nerves
what do mast cells release?
proinflammatory mediators
What proinflamatory cytokines are released from mast cells located in connective tissue/skin?
Histamine
heparin
What proinflammatory cytokines are released from mast cells located in the intestines/lungs
Chondroitin sulfate
few histamine
What is the result of type 1 hypersensitivity?
acute inflammation and systemic effects
Where are mast cells located?
Intestine, skin, around nerves
Used term of the antigen that can trigger type 1 Hypersensitivity?
a. Epitope
b. Autoantigen
c. Isoantigen
d. Allergen
d
T/F. If the rate of release of vasoactive molecules from the mast cells exceeds its ability to adjust to the rapid changes in the vascular system, an animal will undergo allergic anaphylaxis and may die
T
