Exam 1: MHC

Question 1

Which two MHC alleles are responsible for Caprine arthritis encephalitis virus (CAEV)?

Answer 1

Be1 Be14

Question 2

Specialized proteins expressed on antigen presenting cells that present antigens to T cells

Answer 2

MHC molecules

Question 3

What are the 3 classes of MHc

Answer 3

MHC class 1
MHC class 2
MHC class 3

Question 4

What do MHC class 1 loci code for:

Answer 4

MHC molecules that are expressed on all nucleated cells

Question 5

What do MHC class 2 loci code for?

Answer 5

MHC molecules found only on antigen presenting cells

Question 6

What do MHC class 3 loci code for?

Answer 6

Various proteins that do not function as antigen presenting molecules

Question 7

T/F. MHC genes are co-dominantly expressed

Answer 7

T

Question 8

Each individual has ___ MHC 1 genes

Answer 8

6

Question 9

T/F. The MHC molecules define compatibility of a tissue during a transplant

Answer 9

T

Question 10

T/F Recognition of a graft as “self” or “foreign” is an inherited trait

Answer 10

T

Question 11

What name was given to the region in the genome where proteins responsible for graft rejection are encoded

Answer 11

MHC

Question 12

The MHC in cattle is also referred to as:

a. BLA
b. CLA
c. BOLA

Answer 12

c.

Question 13

A set of MHC alleles present on a chromosome

Answer 13

Haplotype

Question 14

MHC class __ and __ are the main antigen presenting molecules

Answer 14

1 and 2

Question 15

Which MHC molecules present peptide antigens to CD8 T cells

Answer 15

class 1

Question 16

Which MHC class is expressed on dendritic cells, macrophages, and b cells?

Answer 16

mhc class 2

Question 17

Which MHC class presents antigens to CD4 T cells

Answer 17

Class 2

Question 18

T/F. MHC class 3 play an important role in antigen presentation

Answer 18

F. Do not play a role in AP

Question 19

Which 3 interferons increase the expression of MHC class 1

Answer 19

IFNa
IFNB
IFNy

Question 20

What type of interferon increases the expression of MHC class 2 on macrophages and dendritic cells

Answer 20

IFNy

Question 21

T/F A foreign antigenic peptide that does not fit the MHC molecule will stimulate an immune response

Answer 21

F. Will not stim. immune response unless fits

Question 22

Apart from tissue compatibility MHC molecules also play a role in

a. generation of protective immune response
b. generation of blood groups
c. generation of ROS and RNS

Answer 22

a. gen. of IR

Question 23

What role do the MHC class 3 molecules play in immunity

a. present antigen ot AB cell
b. Have innate immune functions and do not present antigen
c. they are globulin molecules

Answer 23

b. have innate immune function and do not present antigen

Question 24

Which MHC Molecules are expressed on cells that professionally present antigens?

a. class 1
b. class 2
c. class 3

Answer 24

b. class 2

Question 25

T/F. MHC molecules are required for presentation of antigens to cells of the adaptive immune response

Answer 25

T

Question 26

MHC class 1 molecules consist of

a. two alpha chains
b. one alpha and one b2 microglobulin
c. one alpha and one beta chain
d. two beta chains

Answer 26

c. one alpha one beta

Question 27

The MHC class 2 molecules consist of

a. two alpha chains
b. one alpha chain and one b2 microglobulin
c. one alpha and one beta chain
d. two beta chains

Answer 27

c. one alpha one beta