Exam 1: MHC Flashcards
Which two MHC alleles are responsible for Caprine arthritis encephalitis virus (CAEV)?
Be1 Be14
Specialized proteins expressed on antigen presenting cells that present antigens to T cells
MHC molecules
What are the 3 classes of MHc
MHC class 1 MHC class 2 MHC class 3
What do MHC class 1 loci code for:
MHC molecules that are expressed on all nucleated cells
What do MHC class 2 loci code for?
MHC molecules found only on antigen presenting cells
What do MHC class 3 loci code for?
Various proteins that do not function as antigen presenting molecules
T/F. MHC genes are co-dominantly expressed
T
Each individual has ___ MHC 1 genes
6
T/F. The MHC molecules define compatibility of a tissue during a transplant
T
T/F Recognition of a graft as “self” or “foreign” is an inherited trait
T
What name was given to the region in the genome where proteins responsible for graft rejection are encoded
MHC
The MHC in cattle is also referred to as:
a. BLA
b. CLA
c. BOLA
c.
A set of MHC alleles present on a chromosome
Haplotype
MHC class __ and __ are the main antigen presenting molecules
1 and 2
Which MHC molecules present peptide antigens to CD8 T cells
class 1
Which MHC class is expressed on dendritic cells, macrophages, and b cells?
mhc class 2
Which MHC class presents antigens to CD4 T cells
Class 2
T/F. MHC class 3 play an important role in antigen presentation
F. Do not play a role in AP
Which 3 interferons increase the expression of MHC class 1
IFNa
IFNB
IFNy
What type of interferon increases the expression of MHC class 2 on macrophages and dendritic cells
IFNy
T/F A foreign antigenic peptide that does not fit the MHC molecule will stimulate an immune response
F. Will not stim. immune response unless fits
Apart from tissue compatibility MHC molecules also play a role in
a. generation of protective immune response
b. generation of blood groups
c. generation of ROS and RNS
a. gen. of IR
What role do the MHC class 3 molecules play in immunity
a. present antigen ot AB cell
b. Have innate immune functions and do not present antigen
c. they are globulin molecules
b. have innate immune function and do not present antigen
Which MHC Molecules are expressed on cells that professionally present antigens?
a. class 1
b. class 2
c. class 3
b. class 2
T/F. MHC molecules are required for presentation of antigens to cells of the adaptive immune response
T
MHC class 1 molecules consist of
a. two alpha chains
b. one alpha and one b2 microglobulin
c. one alpha and one beta chain
d. two beta chains
c. one alpha one beta
The MHC class 2 molecules consist of
a. two alpha chains
b. one alpha chain and one b2 microglobulin
c. one alpha and one beta chain
d. two beta chains
c. one alpha one beta
