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Immunology > Exam 1: The Complement > Flashcards

Exam 1: The Complement Flashcards

1
Q

How is the classical pathway activated?

A

binding of C1q to the surface of a pathogen

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2
Q

What are the 3 ways C1q can bind to the surface of a pathogen?

A
  1. directly to the surface
  2. Binds to C reactive P
  3. Binds to antigen-antibody complex
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3
Q

How is the lectin pathway initiated?

A

Binding of carbohydrate binding proteins to carbohydrates on the surface of pathogens

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4
Q

What are the two carbohydrate binding Ps that the lectin pathway can bind?

A

Mannose binding lectin (MBL)

Ficolins

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5
Q

How is the alternative pathway initiated?

A

binding of spontaneously derived plasma C3b to pathogen surfaces

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6
Q

What is the main effector molecule of the complement?

A

C3b

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7
Q

What does C3 convertase cleave?

A

C3 into C3b and C3a

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8
Q

What is the importance of C3a?

A

mediator of inflammation

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9
Q

During recurrent bacterial infection, how is the complement efficiently activated?

a. it cannot be activated b/c the complement system operates only during innate response
b. through mannose binding
c. through AB binding to pathogen
d. through ficolin binding

A

c. through AB binding to pathogen

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10
Q

Which caomplement pathway is initiated by ficolins and MBL?

A

Lectin

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11
Q

What are the two most potent activators of the classical complement pathway?

A

IgM and IgG

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12
Q

What is C3 convertase in the classical pathway?

A

C4b2a

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13
Q

Which fragment of C3 attaches to the surface of microbes

A

C3b

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14
Q

When C3b attaches to the surface of a microbe and thus tagging it for destruction.

A

opsonization

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15
Q

What is c5 convertase in the classical pathway?

A

C4b2a3b

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16
Q

The most abundant complement protein is

a. C2a
b. C3b
c. C3
d. C5b

A

c. C3

17
Q

C3a and C5a are products of which reaction?

a. Cleavage of C3 by C5 convertase
b. Cleavage of C5 by C3 convertase
c. Cleavage of C3 and C5 by C3 and C5 convertase
d. All of the above

A

C

18
Q

T/F. C3b is an important C3 cleavage product which acts in opsonization.

A

T

19
Q

T/F. Activation of the lectin pathway is an independent adaptive immune response.

A

F. Innate immune response

20
Q

How does the alternative pathway activate

A

spontaneous cleavage of C3

21
Q

What stabilizes C3 convertase in the alternative pathway?

A

Properdin

22
Q

What is C5 convertase in the alternative pathway?

A

C3bBb3b

23
Q

List 4 complement control proteins

A
  1. C1 inhibitor
  2. Factor H
  3. Decay accelerating factor
  4. Protectin

Immunology (23 decks)

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