Exam 2: Regulation of the Immune Response

Question 1

When there is not an immune response to a specific antigen

Answer 1

tolerance

Question 2

What are the two types of Lymphocyte tolerance

Answer 2

1. Central

2. Peripheral

Question 3

Type of tolerance where immature self reactive lymphocytes withing thymus, bursa, or bone marrow die or alter their receptor specificity

Answer 3

Central tolerance

Question 4

Type of tolerance where mature lymphocytes that encounter self antigens are turned off, or suppressed

Answer 4

Peripheral tolerance

Question 5

What is the function of central T cell tolerance?

Answer 5

Make sure there are no functional T cells with receptors that bind to self antigens

Question 6

What is the point of Negative selection with regards to Central T cell tolerance

Answer 6

cells with non functional TCRs will be eliminated

Question 7

What is the point of positive selection with regards to Central T cell tolerance.

Answer 7

ensures that cells that recognize self MHC molecules survive

Question 8

The prolonged antigen specific suppression of T cell function

Answer 8

Clonal Anergy

Question 9

What are 3 ways of Central B cell tolerance?

Answer 9

1. VDJ rearrangement
2. Gene conversion
3. somatic mutation