Exam 2: Cellular Immune Response 1-3

Question 1

The cellular immune response provided by T cells provides immunity against what 5 things?

Answer 1

1. intracellular bacteria
2. intracellular virus
3. fungi
4. protozoa
5. tumors

Question 2

Endogenous antigens are processed and presented on MHC type ___

Answer 2

1

Question 3

2 main mechanisms that cells can be destroyed by cellular immune response

Answer 3

1. infected cells killed

2. infected cells are activated and destroy the intracellular organism.

Question 4

What are the 3 Caspases in inflammation and apoptosis

Answer 4

1. initiator caspases
2. Effector caspases
3. inflammatory caspases

Question 5

Which caspase is activated by multimolecular inflammasomes

Answer 5

inflammatory caspases

Question 6

Which caspases are activated by multimolecular death complexes?

Answer 6

initiator

Question 7

Which caspases breakdown cellular structures?

Answer 7

effector caspases

Question 8

What are the 2 pathways by which macrophages can be activated

Answer 8

1. Innate Pathway- involves IFN-y production by NK cells

2. Adaptive pathway- mediated by IFN-y from Th1 cells

Question 9

T/F. T cell cytotoxicity induces apoptosis on the target cell by the activation of caspase cascade

Answer 9

T

Question 10

T/F. The extrinisc and intrinsic pathways triggers a cascade of enzyme activation to induce apoptosis on the target cell. these pathways are activated by the interaction of the T cell receptor and the MHC type I + Antigen

Answer 10

T

Question 11

T/F. Suprantigens do not require MHC Antigen presentation

Answer 11

T

Question 12

T/F. Suprantigens bind to the a chain of the antibody?

Answer 12

F. B chain only

Question 13

What are the 3 subpopulations of CD4 Helper T cells and what do they do?

Answer 13

Th1- Cellular IR
Th2-humoral IR
Th17- Inflam.

Question 14

What two things do Th 1 cells produce?

Answer 14

1. IL-2

2. IF-y

Question 15

What are the 3 functions of IF-y from Th1 cell:

Answer 15

1. activates NK cells
2. Activates Macrophages
3. Antiviral

Question 16

What are the functions of IL-2 produced by Th1 cells?

Answer 16

1. promotes B cell proliferation

2. Promotes Th1 Activation

Question 17

If Helper T cells come into contact with IL-4 they will differentiate into Th__

Answer 17

Th2

Question 18

If Helper T cells come into contact with IL-12 they will differentiate into Th__

Answer 18

Th1

Question 19

What are the 2 major functions of Th17?

Answer 19

1. produce proinflammatory cytokines

2. potent B cell helper

Question 20

T/F y/d T cells can be either innate or adaptive.

Answer 20

T

Question 21

Where are innate y/d T cells found?

Answer 21

skin and uterus

Question 22

Where are adaptive y/d T cells found?

Answer 22

GI tract and 2ndary lymphoid organs

Question 23

Which Y/d T cells are limited TCR and which are Polyclonal?

Answer 23

Innate

Adaptive

Question 24

Cellular immune response is directed to eliminate:

a. cancer cells
b. intracellular bacteria
c. intracellular parasites
d. all of the above
e. A and b.

Answer 24

d. all of above

Question 25

T/F. Absence of co-stimulatory signals mediated by the CD3 activation can inhibit/avoid the triggering of the cellular immune response.

Answer 25

T