Exam 2: Cellular Immune Response 1-3 Flashcards
The cellular immune response provided by T cells provides immunity against what 5 things?
- intracellular bacteria
- intracellular virus
- fungi
- protozoa
- tumors
Endogenous antigens are processed and presented on MHC type ___
1
2 main mechanisms that cells can be destroyed by cellular immune response
- infected cells killed
2. infected cells are activated and destroy the intracellular organism.
What are the 3 Caspases in inflammation and apoptosis
- initiator caspases
- Effector caspases
- inflammatory caspases
Which caspase is activated by multimolecular inflammasomes
inflammatory caspases
Which caspases are activated by multimolecular death complexes?
initiator
Which caspases breakdown cellular structures?
effector caspases
What are the 2 pathways by which macrophages can be activated
- Innate Pathway- involves IFN-y production by NK cells
2. Adaptive pathway- mediated by IFN-y from Th1 cells
T/F. T cell cytotoxicity induces apoptosis on the target cell by the activation of caspase cascade
T
T/F. The extrinisc and intrinsic pathways triggers a cascade of enzyme activation to induce apoptosis on the target cell. these pathways are activated by the interaction of the T cell receptor and the MHC type I + Antigen
T
T/F. Suprantigens do not require MHC Antigen presentation
T
T/F. Suprantigens bind to the a chain of the antibody?
F. B chain only
What are the 3 subpopulations of CD4 Helper T cells and what do they do?
Th1- Cellular IR
Th2-humoral IR
Th17- Inflam.
What two things do Th 1 cells produce?
- IL-2
2. IF-y
What are the 3 functions of IF-y from Th1 cell:
- activates NK cells
- Activates Macrophages
- Antiviral
What are the functions of IL-2 produced by Th1 cells?
- promotes B cell proliferation
2. Promotes Th1 Activation
If Helper T cells come into contact with IL-4 they will differentiate into Th__
Th2
If Helper T cells come into contact with IL-12 they will differentiate into Th__
Th1
What are the 2 major functions of Th17?
- produce proinflammatory cytokines
2. potent B cell helper
T/F y/d T cells can be either innate or adaptive.
T
Where are innate y/d T cells found?
skin and uterus
Where are adaptive y/d T cells found?
GI tract and 2ndary lymphoid organs
Which Y/d T cells are limited TCR and which are Polyclonal?
Innate
Adaptive
Cellular immune response is directed to eliminate:
a. cancer cells
b. intracellular bacteria
c. intracellular parasites
d. all of the above
e. A and b.
d. all of above
T/F. Absence of co-stimulatory signals mediated by the CD3 activation can inhibit/avoid the triggering of the cellular immune response.
T
