Final Exam: Immunomodulation

Question 1

What are the 2 outcomes of immunomodulation immunopharmacology?

Answer 1

1. suppression of the IR

2. Stimulation of the IR

Question 2

What is the effect of cortico steroids on the IS?

Answer 2

stimulate the synthesis of excessive amts. of IkBa which binds to NF-kB and continues to prevent its activation

Question 3

What is the target of cyclosporine and what is its effect?

Answer 3

Calcineruin

inhibits signal trasduction and synthesis of IL2 and IFNy

Question 4

What is the target of tocrolimus and what is the effect?

Answer 4

Calcineurin

inhibition of production of IL2-5 INFy and TNFa

Question 5

What is the target of Rapamycin and what is the effect?

Answer 5

m-TOR

Blocks stimulatory signals rom IL2, IL4, IL6

Question 6

What is the target of mycophenolate and what is the effect?

Answer 6

DNA

prevents synthesis of DNA, blocks B and T cell proliferation

Question 7

What is the target of lefunomide ane what is the effect?

Answer 7

DNA

production of T reg cells

Question 8

WHat is the target of antiserum and what is the effect?

Answer 8

CD3, CD4, CD8

Depletion of lymphocytes

Question 9

What is the target and effect of Antibodies Intravenous Immunoglobulin Thereapy (IVIG)

Answer 9

CD32

inhibit humoral immune resp.

Question 10

What 5 compounds stimulate the IR?

Answer 10

1. Bacille Calmette-Guerin Mycobacterium Bovis
2. Complex carbs
3. levamisole
4. Vite. A D and E
5. Cytokines

Question 11

What are the 3 effects of using Yatrenic Acid in animals?

Answer 11

1. inc leukocytosis
2. Inc T cells
3. inc. cytokines