Exam 2: Humoral Immune Response 1 Flashcards
What are the two types of antigens in the adaptive immune response
- intracellular
2. extracellular
Which adaptive immune response do intracellular antigens contribute to?
Cellular immune response
Which adaptive immune response do extracellular antigens contribute to?
Humoral immune response
What are the two types of humoral immune response?
- passive
2. active
What is the artificial component of the passive humoral response?
immunoglobulins
What is the natural component of the passive humoral response?
transplacental, colostrum, egg, antibodie transport
What is the artivical component of the active humoral response?
vaccination
What is the natural component of the active humoral immune response?
disease
what is active humoral immune response?
animal makes its own antibodies
What is passive humoral immune response
animal is given antibodies from other animal.
What are the two parts of the antibody?
Fab and Fc
what are the 2 proteins that make up the antibody?
light chain and heavy chain
What are the 4 types of light chain?
- constant domain
- variable domain
3 light kappa chain - light lambda chain
What are the 2 parts of the heavy chain?
- variable domain
2. constant domain
What are the 5 diff types of heavy chains
alpha gamma delta epsilon mue
constant regions among hypervariable regions are called:
framework regions
hypervariable regions are known as:
CDR’s (complementary determining regions)
how many constant domains does alpha, gamma, and delta have?
3
How many constant domains does mue and epsilon have?
4
What is the complement receptor for C3?
CD21
What is the signaling component?
CD19
What are the 4 B lymphocyte Co-stimulation ILs?
- IL-4
- IL-5
- IL-6
- IL-13
Can b cells or t cells bind to free soluble antigen?
BCRs
Which lymphocyte requires mhc molecules to recognize?
TCRs
PAMPs bind to TLRs on B cells causing b cell ____ and _____
activation and proliferation
do b cells or t cells recognize native epitopes?
B cells
t cells recognize processed epitopes
T/F. more plasma cells produce IgG than IgM in the primary immune resp.
F. more produce IgM
T/F. more plasma cells produce IgG than IgM in the secondary immune resp.
T
what are the 2 populations of plasma cells?
short lived and long lived
where are short lived plasma cells found?
spleen and lymph nodes
Where are long lived plasma cells found?
bone marrow
What are the 5 classes of antibodies?
- IgG
- IgM
- IgA
- IgD
- IgE
Which class of antibody is the most numerous in serum?
IgG
Which class of antibody is the most numerous in saliva, milk, and GI fluids?
IgA
Which class of antibodies is the least numerous in serum?
IgE
Which class of antibodies is important for inflammation, agglutination, and opsonization?
IgG
Which class of antibodies activates the classical complement pathway?
igG
Which class of antibodies is important for opsonization, virus neutralization and agglutination?
IgM
Where is IgA located?
body surfaces
What happens when IgE is bound to antigen?
inflammation
Which classs of antibodies is responsible for inflammation and immunity against parasites?
IgE
which Ig has the shortest 1/2 life?
IgE
Which class of antibodies mediates the link between innate and adaptive immune response?
IgD
Which Ig is found in plasma cells in body surfaces?
IgA
Which Ig is the major Ig in external secretions of non ruminants?
IgA
T/F IgA activates the compliment pathway?
F
Which Ig is produced by plasma cells located under body surfaces?
IgE
What is IgE attached to on mast cells and basophils?
FcERI
IgE bound to antigen causes _____.
inflammation
What does IgE cause mast cells to do?
release inflammatory molecules
T/F. IgE is important for immunity against parasites
T
Which Ig has the shortest half life?
IgE
Which species does not have IgD
cats, chicken rabbits
IgD is mainly attached to ____.
B cells
Ig that mediates the link between innate and adaptive immune response
IgD