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Exam 2: Humoral Immune Response 1 Flashcards

1
Q

What are the two types of antigens in the adaptive immune response

A
  1. intracellular

2. extracellular

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2
Q

Which adaptive immune response do intracellular antigens contribute to?

A

Cellular immune response

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3
Q

Which adaptive immune response do extracellular antigens contribute to?

A

Humoral immune response

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4
Q

What are the two types of humoral immune response?

A
  1. passive

2. active

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5
Q

What is the artificial component of the passive humoral response?

A

immunoglobulins

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6
Q

What is the natural component of the passive humoral response?

A

transplacental, colostrum, egg, antibodie transport

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7
Q

What is the artivical component of the active humoral response?

A

vaccination

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8
Q

What is the natural component of the active humoral immune response?

A

disease

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9
Q

what is active humoral immune response?

A

animal makes its own antibodies

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10
Q

What is passive humoral immune response

A

animal is given antibodies from other animal.

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11
Q

What are the two parts of the antibody?

A

Fab and Fc

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12
Q

what are the 2 proteins that make up the antibody?

A

light chain and heavy chain

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13
Q

What are the 4 types of light chain?

A
  1. constant domain
  2. variable domain
    3 light kappa chain
  3. light lambda chain
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14
Q

What are the 2 parts of the heavy chain?

A
  1. variable domain

2. constant domain

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15
Q

What are the 5 diff types of heavy chains

A 
alpha
gamma
delta
epsilon
mue
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16
Q

constant regions among hypervariable regions are called:

A

framework regions

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17
Q

hypervariable regions are known as:

A

CDR’s (complementary determining regions)

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18
Q

how many constant domains does alpha, gamma, and delta have?

A

3

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19
Q

How many constant domains does mue and epsilon have?

A

4

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20
Q

What is the complement receptor for C3?

A

CD21

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21
Q

What is the signaling component?

A

CD19

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22
Q

What are the 4 B lymphocyte Co-stimulation ILs?

A
  1. IL-4
  2. IL-5
  3. IL-6
  4. IL-13
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23
Q

Can b cells or t cells bind to free soluble antigen?

24
Q

Which lymphocyte requires mhc molecules to recognize?

25
PAMPs bind to TLRs on B cells causing b cell ____ and _____
activation and proliferation
26
do b cells or t cells recognize native epitopes?
B cells t cells recognize processed epitopes
27
T/F. more plasma cells produce IgG than IgM in the primary immune resp.
F. more produce IgM
28
T/F. more plasma cells produce IgG than IgM in the secondary immune resp.
T
29
what are the 2 populations of plasma cells?
short lived and long lived
30
where are short lived plasma cells found?
spleen and lymph nodes
31
Where are long lived plasma cells found?
bone marrow
32
What are the 5 classes of antibodies?
1. IgG 2. IgM 3. IgA 4. IgD 5. IgE
33
Which class of antibody is the most numerous in serum?
IgG
34
Which class of antibody is the most numerous in saliva, milk, and GI fluids?
IgA
35
Which class of antibodies is the least numerous in serum?
IgE
36
Which class of antibodies is important for inflammation, agglutination, and opsonization?
IgG
37
Which class of antibodies activates the classical complement pathway?
igG
38
Which class of antibodies is important for opsonization, virus neutralization and agglutination?
IgM
39
Where is IgA located?
body surfaces
40
What happens when IgE is bound to antigen?
inflammation
41
Which classs of antibodies is responsible for inflammation and immunity against parasites?
IgE
42
which Ig has the shortest 1/2 life?
IgE
43
Which class of antibodies mediates the link between innate and adaptive immune response?
IgD
44
Which Ig is found in plasma cells in body surfaces?
IgA
45
Which Ig is the major Ig in external secretions of non ruminants?
IgA
46
T/F IgA activates the compliment pathway?
F
47
Which Ig is produced by plasma cells located under body surfaces?
IgE
48
What is IgE attached to on mast cells and basophils?
FcERI
49
IgE bound to antigen causes _____.
inflammation
50
What does IgE cause mast cells to do?
release inflammatory molecules
51
T/F. IgE is important for immunity against parasites
T
52
Which Ig has the shortest half life?
IgE
53
Which species does not have IgD
cats, chicken rabbits
54
IgD is mainly attached to ____.
B cells
55
Ig that mediates the link between innate and adaptive immune response
IgD

Immunology (23 decks)

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