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Immunology > Exam 2: Humoral Immune Response 1 > Flashcards

Exam 2: Humoral Immune Response 1 Flashcards

1
Q

What are the two types of antigens in the adaptive immune response

A
  1. intracellular

2. extracellular

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2
Q

Which adaptive immune response do intracellular antigens contribute to?

A

Cellular immune response

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3
Q

Which adaptive immune response do extracellular antigens contribute to?

A

Humoral immune response

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4
Q

What are the two types of humoral immune response?

A
  1. passive

2. active

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5
Q

What is the artificial component of the passive humoral response?

A

immunoglobulins

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6
Q

What is the natural component of the passive humoral response?

A

transplacental, colostrum, egg, antibodie transport

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7
Q

What is the artivical component of the active humoral response?

A

vaccination

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8
Q

What is the natural component of the active humoral immune response?

A

disease

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9
Q

what is active humoral immune response?

A

animal makes its own antibodies

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10
Q

What is passive humoral immune response

A

animal is given antibodies from other animal.

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11
Q

What are the two parts of the antibody?

A

Fab and Fc

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12
Q

what are the 2 proteins that make up the antibody?

A

light chain and heavy chain

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13
Q

What are the 4 types of light chain?

A
  1. constant domain
  2. variable domain
    3 light kappa chain
  3. light lambda chain
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14
Q

What are the 2 parts of the heavy chain?

A
  1. variable domain

2. constant domain

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15
Q

What are the 5 diff types of heavy chains

A 
alpha
gamma
delta
epsilon
mue
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16
Q

constant regions among hypervariable regions are called:

A

framework regions

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17
Q

hypervariable regions are known as:

A

CDR’s (complementary determining regions)

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18
Q

how many constant domains does alpha, gamma, and delta have?

A

3

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19
Q

How many constant domains does mue and epsilon have?

A

4

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20
Q

What is the complement receptor for C3?

A

CD21

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21
Q

What is the signaling component?

A

CD19

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22
Q

What are the 4 B lymphocyte Co-stimulation ILs?

A
  1. IL-4
  2. IL-5
  3. IL-6
  4. IL-13
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23
Q

Can b cells or t cells bind to free soluble antigen?

A

BCRs

24
Q

Which lymphocyte requires mhc molecules to recognize?

A

TCRs

25
Q

PAMPs bind to TLRs on B cells causing b cell ____ and _____

A

activation and proliferation

26
Q

do b cells or t cells recognize native epitopes?

A

B cells

t cells recognize processed epitopes

27
Q

T/F. more plasma cells produce IgG than IgM in the primary immune resp.

A

F. more produce IgM

28
Q

T/F. more plasma cells produce IgG than IgM in the secondary immune resp.

A

T

29
Q

what are the 2 populations of plasma cells?

A

short lived and long lived

30
Q

where are short lived plasma cells found?

A

spleen and lymph nodes

31
Q

Where are long lived plasma cells found?

A

bone marrow

32
Q

What are the 5 classes of antibodies?

A
  1. IgG
  2. IgM
  3. IgA
  4. IgD
  5. IgE
33
Q

Which class of antibody is the most numerous in serum?

A

IgG

34
Q

Which class of antibody is the most numerous in saliva, milk, and GI fluids?

A

IgA

35
Q

Which class of antibodies is the least numerous in serum?

A

IgE

36
Q

Which class of antibodies is important for inflammation, agglutination, and opsonization?

A

IgG

37
Q

Which class of antibodies activates the classical complement pathway?

A

igG

38
Q

Which class of antibodies is important for opsonization, virus neutralization and agglutination?

A

IgM

39
Q

Where is IgA located?

A

body surfaces

40
Q

What happens when IgE is bound to antigen?

A

inflammation

41
Q

Which classs of antibodies is responsible for inflammation and immunity against parasites?

A

IgE

42
Q

which Ig has the shortest 1/2 life?

A

IgE

43
Q

Which class of antibodies mediates the link between innate and adaptive immune response?

A

IgD

44
Q

Which Ig is found in plasma cells in body surfaces?

A

IgA

45
Q

Which Ig is the major Ig in external secretions of non ruminants?

A

IgA

46
Q

T/F IgA activates the compliment pathway?

A

F

47
Q

Which Ig is produced by plasma cells located under body surfaces?

A

IgE

48
Q

What is IgE attached to on mast cells and basophils?

A

FcERI

49
Q

IgE bound to antigen causes _____.

A

inflammation

50
Q

What does IgE cause mast cells to do?

A

release inflammatory molecules

51
Q

T/F. IgE is important for immunity against parasites

A

T

52
Q

Which Ig has the shortest half life?

A

IgE

53
Q

Which species does not have IgD

A

cats, chicken rabbits

54
Q

IgD is mainly attached to ____.

A

B cells

55
Q

Ig that mediates the link between innate and adaptive immune response

A

IgD

Immunology (23 decks)

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