Final Exam: Immunodeficiency Flashcards
impairment of part or parts of the IS that renders the immunodeficient patient to be more susceptible to infectious disease
Immunodeficiency
what are the 2 types of immunodeficiencies?
- Primary
2. Secondary
What type of immunodeficiency is characterized by: mutation in a gene
Primary
What type of immunodeficiency is charactarized by adult animals that have had previous normal immune function.
Secondary
What are the 8 levels of primary immunodeficiencies?
Failure of:
- pluripotent stem cells
- committed stem cells
- B cell development
- T cell development
- B cell mutation to plasma cells
- production of Ig classes
- phagocytic cells
- production of complement molecules
Treatments of primary immuno deficiencies?
- BM transplant
- Stem cell transplant
- gene therapy
What is Thymic aplasia
Primary immunodeficiency where there is a lack of T cell linked to failure of development of hair coat
What are zinc associated disorders
primary immunodeficiency where there is a reduce absorption of zinc
in Bull terriers what are some effects of zinc associated disorders
- lymphocyte disfunction
- subnormal plasma zinc levels
3 severe cutaneous parakeratosis - reduced t cell mitogagen response
Neutrophil disorders are primary or secondary immunodeficiencies?
primary
What are 4 examples of neutrophil disorders?
- trapped neutrophils syndrome
- chediak higashi syndrome
- cyclic hematopoiesis
- Leukocyte adhesion deficiency
Neutrophil disorder characterized by defective neutrophil function causing abnormal fusionof lysosomal memb.
chediak higashi syndrome
Neutrophil disorder characterized by cyclic neutropenia associated with episoded of infection
cyclic hematopoiesis
Type of deutrophil disorder characterized by mutation on integrin gene causing neutrophils to not migrate into tissues which makes patient susceptible to multiple infections
leukocyte adhesion deficiency
Selective immunoglobulin deficiency is primary or secondary immunodeficiency
primary
What is Selective immunoglobulin deficiency (SID)?
IgA deficiency
C/S: Mild chronic recurrent mucosal infections
Primary immunodeficiency where there is a deficiency in C3 or Factor H
Complement deficiency
Immunodeficiencies that affect adult animals
secondary
What are 3 characteristics of immunosenescence?
- dec. in CD4 T cells
- Inc. in CD8 T cells
- Susceptible to infections
What are 2 examples of medical immunosuppression
- chemo
2. immunosuppressive therapy
Immunosenescence primary or secondary ID?
secondary
Medical immunodeficiencies primary or secondary ID?
Secondary
FIV and FeLV are examples of what type of immunodeficiency?
secondary
