Final Exam: Autoimmunity

Question 1

what cells are involved in autoimmunity

Answer 1

B and T cells

Question 2

What % of BCR and TCR recognize self antigens?

Answer 2

20%

Question 3

3 factors relating to automimmunity?

Answer 3

1. Sex
2. Age
3. Virus

Question 4

What are the 2 categories of autoimmunity/

Answer 4

1. immune response to abnormal antigen

2. abnormal immune response to normal antigen

Question 5

Milk allergy is what type of hypersensitivity?

Answer 5

Type 1

Question 6

Ab agains RBCs is what type of hypersensitivity.

Answer 6

Type 2

Question 7

SLE iswhat type of hypersensitivyt?

Answer 7

Type 3

Question 8

Encephalitism MS, Diabetes is what type of hypersensitivity?

Answer 8

Type 4

Question 9

Organ specific Autoimmune Diseases:

Answer 9

1. Autoimmune thyroiditis
2. Insulin dependent Diabetes mellitus
3. Lymphocytic pancreatitis
4. Lymphocyte mediated destruction of the adrenal cortex

Question 10

What is immune mediated hemolytic anemia?

Answer 10

RBC membrane altered by Bacteria, virus, drugs. . .

Question 11

What is Autoimmune Thrombocytopenia

Answer 11

Ab against platelets antigens

Question 12

how many classes of immune mediated hemolytic anemias are there?

Answer 12

5

Question 13

What is the predominant antibody in each type of IMHA

Answer 13

1. G
2. M
3. G
4. M
5. M

Question 14

In systemic lupus erythematosus (SLE) what are there Ab against?

Answer 14

1. Nucleic Acids
2. Ribonucleoproteins
3. Chromatin
4. Histone
5. RBC
6. Muscle cells
7. Skin BM

Question 15

SLE is associated with what 4 things?

Answer 15

1. inc. IFNy
2. TLR7 and TLR9
3. Bacterial DNA
4. Ultraviolet radiation

Question 16

What are the 2 ways animals get Arthritis rheumatoid (AR)

Answer 16

1. abnormal immunoglobulin glycosylation

2. Infectious antigen + Genetic Background

Question 17

What are the 4 autoimmune responses in the joints in AR?

Answer 17

1. Th 17 activation
2. Anti IgG
3. Anti-type 2 collagen
4. Anti-glycosaminoglycans