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Immunology > Exam 2: Lymphocytes and Co-stimulatory Receptors > Flashcards

Exam 2: Lymphocytes and Co-stimulatory Receptors Flashcards

1
Q

Which immune response does NK cells belong to?

A

Innate immune response

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2
Q

Which immune response does T cells belong to?

A

Cellular immune response

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3
Q

Which immune response does B cells belong to?

A

Humoral immune response

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4
Q

Which section of the lymph node houses T cells?

A

Paracortex

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5
Q

Which section of the lymph node houses B cells?

A

Cortex

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6
Q

Which zone of the spleen contains B cells?

A

Marginal zone

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7
Q

What are the two antigen binding chains of the TCR?

A

1 TCR a/b

2. TCR y/d

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8
Q

What are the 5 BCR antigen binding chains:

A

BCR: a, y, u, e, d

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9
Q

Is CD3 found in T cells or B cells?

A

T cells

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10
Q

What are the four major populations with antigen-binding receptors

A
  1. Helper T cells
  2. Cytotoxic T Cells
  3. Regulatory T cells
  4. B cells
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11
Q

Which of the 4 major populations with antigen binding receptors regulate the immune response?

A

Helper T cells

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12
Q

Which of the 4 major populations with antigen binding receptors destroy cells expressing endogenous antigens

A

Cytotoxic T cells

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13
Q

Which of the 4 major populations with antigen binding receptors destroy cells expressing endogenous antigens

A

Cytotoxic T cells

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14
Q

Which of the 4 populations with antigen binding receptors produce antibodies?

A

B cells

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15
Q

These are molecules/receptors that can regulate the lymphocyte function

a. cytokines
b. antibodies
c. complement
d. antigen
e. all of the above

A

e. all of above

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16
Q

T/F CD4 and CD8 are expressed on B cells and NK cells

A

F. On T cells only

17
Q

How many TCR are on each T cell?

A

2

18
Q

How many BCRs are on B cells?

A

5

19
Q

The CD3 complex is made of how many protein chains?

A

5

20
Q

What are the 4 co-stimulatory signals of T cells?

A
  1. CD40-CD154
  2. CD28-CD80
  3. CD38 - CD86
  4. CD152-CD80/86
21
Q

What is the effect of CD28-CD86 costimulatory signal

A
  1. upregulate survival genes
  2. inc. energy metabolism
  3. promotes t cell division
22
Q

What is the effect of CD152-CD80/86 costimulatory signal?

A

T cell response termination

23
Q

T/F. The variable domain of the TCR is explicit for binding a specific antigen

A

T

24
Q

What determines humoral vs. cellular response

A

DC present

25
Q

T/F. TCR, BCR, MHC I, and MHCII are not members of the immunoglobulin superfamily

A

F

26
Q

If a processed and presented antigen bind in a correct manner on a t cell. t cell is activated and initiates the immune response by:

a. cytokine production
b. mitosis
c. cell differentiation
d. all of above

A

d. all of above

27
Q

T/F. CD3 is found in all t cells and it has a main role in the signal transduction into the t cell

A

T

Immunology (23 decks)

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