Exam 2: Lymphocytes and Co-stimulatory Receptors Flashcards
Which immune response does NK cells belong to?
Innate immune response
Which immune response does T cells belong to?
Cellular immune response
Which immune response does B cells belong to?
Humoral immune response
Which section of the lymph node houses T cells?
Paracortex
Which section of the lymph node houses B cells?
Cortex
Which zone of the spleen contains B cells?
Marginal zone
What are the two antigen binding chains of the TCR?
1 TCR a/b
2. TCR y/d
What are the 5 BCR antigen binding chains:
BCR: a, y, u, e, d
Is CD3 found in T cells or B cells?
T cells
What are the four major populations with antigen-binding receptors
- Helper T cells
- Cytotoxic T Cells
- Regulatory T cells
- B cells
Which of the 4 major populations with antigen binding receptors regulate the immune response?
Helper T cells
Which of the 4 major populations with antigen binding receptors destroy cells expressing endogenous antigens
Cytotoxic T cells
Which of the 4 major populations with antigen binding receptors destroy cells expressing endogenous antigens
Cytotoxic T cells
Which of the 4 populations with antigen binding receptors produce antibodies?
B cells
These are molecules/receptors that can regulate the lymphocyte function
a. cytokines
b. antibodies
c. complement
d. antigen
e. all of the above
e. all of above
T/F CD4 and CD8 are expressed on B cells and NK cells
F. On T cells only
How many TCR are on each T cell?
2
How many BCRs are on B cells?
5
The CD3 complex is made of how many protein chains?
5
What are the 4 co-stimulatory signals of T cells?
- CD40-CD154
- CD28-CD80
- CD38 - CD86
- CD152-CD80/86
What is the effect of CD28-CD86 costimulatory signal
- upregulate survival genes
- inc. energy metabolism
- promotes t cell division
What is the effect of CD152-CD80/86 costimulatory signal?
T cell response termination
T/F. The variable domain of the TCR is explicit for binding a specific antigen
T
What determines humoral vs. cellular response
DC present
T/F. TCR, BCR, MHC I, and MHCII are not members of the immunoglobulin superfamily
F
If a processed and presented antigen bind in a correct manner on a t cell. t cell is activated and initiates the immune response by:
a. cytokine production
b. mitosis
c. cell differentiation
d. all of above
d. all of above
T/F. CD3 is found in all t cells and it has a main role in the signal transduction into the t cell
T
