Exam 2 - Introduction to Food Animal Respiratory Disease Flashcards
what animals are predisposed to developing mycotic or bacterial granulomas?
no age, breed, or seasonal predilections - cases appear sporadically
what is the pathogenesis of mycotic/bacterial granulomas?
inoculation of eroded nasal mucosa with fungal spores or filamentous bacteria from the environment
what are some common differentials for mycotic/bacterial granuloma?
allergic rhinitis
foreign bodies
tumors
nasal actinobacillosis
oestrus ovis - small ruminants
what is the prevention for mycotic/bacterial granulomas?
there is none - animals breath in things from the dirt
what may accentuate clinical signs associated with mycotic/bacterial granulomas?
heat & dust in the environment
what is the treatment for mycotic/bacterial granulomas?
surgical excision & long term sodium iodine therapy
what is the prognosis of mycotic/bacterial granulomas?
decent to good
what do mycotic/bacterial granulomas look like?
single to multiple, unilateral
anywhere in the nasal cavity
yellow/green, red, nodules or polyps
how are mycotic/bacterial granulomas diagnosed?
endoscopy, biopsy, culture
what do mycotic/bacterial granulomas look like on histopath?
granulation tissues with eosinophils, mononuclear cells, sporangia, +/- hyphae, +/- filamentous bacteria
what are the clinical signs associated with mycotic/bacterial granulomas?
stridor, dyspnea, mucopurulent nasal discharge, epistaxis, rubbing nose, reduced airflow & open mouth breathing in advanced cases
what breed/age of cows are predisposed to allergic rhinitis & enzootic nasal granulomas?
channel island & friesians - familial association reported
6 months to 2 years old
what animals are typically affected by allergic rhinitis & enzootic nasal granulomas?
cattle & possible sheep
what is usually the inciting antigen of allergic rhinitis & enzootic nasal granulomas?
fungal spore
or plant pollen
what is the pathogenesis of allergic rhinitis & enzootic nasal granulomas?
inciting antigen of pollen or fungal spore - homocytotropic antibody develops & re-exposure causes localized, ongoing type 1 hypersensitivity
what happens with chronic allergic rhinitis & enzootic nasal granulomas? what is it indicative of?
hyperplasia, metaplasia, mucosal hypersecretion, & granulomatous inflammation of nasolacrimal tissues
type IV hypersensitivity reaction
what type of year will you see more problems with allergic rhinitis & enzootic nasal granulomas?
warm, moist conditions
how is allergic rhinitis & enzootic nasal granulomas diagnosed?
eosinophil counts in nasal secretions correlate with susceptibility of the animal & activity of the disease
use endoscopy, biopsy, cultures, antigen detection (viruses, bacteria, fungi), & serology to rule out
what is the end stage clinical sign associated with allergic rhinitis & enzootic nasal granulomas?
enzootic granulomas diffusely disseminated in the nasal cavity - constant clinical signs that get worse with warm/moist seasons
what are the clinical signs associated with allergic rhinitis & enzootic nasal granulomas?
sneezing, nasal pruritus, acute dyspnea, stertorous inspiration, profuse nasal discharge, head shaking, & facial swelling
what are the clinical signs of severe cases of allergic rhinitis & enzootic nasal granulomas?
tachypnea, hyperpnea, nasal mucosal ulceration, & may result in foreign bodies from so much face rubbing
what do the granulomas look like in enzootic nasal granulomas?
multiple, firm, white, raised nodules, 1-2mm in diameter
what is the major differential to consider for allergic rhinitis & enzootic nasal granulomas?
fungal granulomas
other than fungal granulomas, what other differentials should be considered for allergic rhinitis & enzootic nasal granulomas?
foreign bodies, respiratory viruses, actinomycosis/actinobacillosis, tumors, o. ovis in small ruminants, or chemical irritants