ECM Flashcards
define ECM
network of macromolecules that occupy the extracellular space
what makes the ECM
connective tissue/cell
functions of ECM
protect
support
strength
signal
what does the ECM store
growth factors
what is the ECM used for
cell adhesion/migration
what occurs with malignant cells
continue to grow without ECM or connection with other cells
what happens when cells do not have ECM
programmed cell death by anoikis
ECM proteins 6
collagen elastin fibronectin laminin proteoglycans minerals
how is elastin secreted
soluble formed linked by disulphide bridges
what is fibronectin
large protein or 2 almsot identical protein (dimer)
functions of fibronectin
support and strength
interactions with other ECM proteins
fucntio of laminin
binding site for cell/protiens
what is laminin a component of
basal lamina
what is the basal lamina
layer of the basement membrane
what are proteoglycans
protein backbone with polysaccharide side chains