Drugs & Receptors Flashcards
Name some drug targets
ion channels, enzymes, carriers
What drugs target ion channels
lignocaine, apamin, nifedipine
What does lignocaine bind to
voltage gated sodium channels
What is the effect of lignocaine
stops action potential firing, stops transmission of pain
What does apamin effect
potassium channels
What do dihydropyridines target
voltage gated calcium channels - heart
What do dihydropyridines treat
high BP
Name an ACE inhibitor
captopril
What does captopril treat
low BP
What does aspirin inhibit
COX enzyme
What drugs target enzymes?
aspirin, pargyline, captopril
What are pargyline and clorgyline
anti-depressants
What does pargyline inhibit
enzyme MAO-B
What is the effect of pargyline
prevents neurotransmitters being broken down
What drug binds to sodium potassium ATPase
digoxin
What does digoxin treat
heart failure
What is fluoxetine
anti-depressant
What is the effect of fluoxetine
binds and inhibits serotonin transporter
What is the effect of agonist binding to ligand gated ion channels
channels open
What is usually the agonist for ligand gated ion channels
ACh
How many times do GPCRs span the membrane
7 times