Autonomic and Cardiovascular Pharmacology Flashcards
What are the neurotransmitters fo the PNS
ACh
What neurotransmitter is used by pre-ganglionic neurons in sympathetic and parasympathetic systems
ACh
What are the target of parasympathetic system on the post ganglionic neuron
muscarinic receptors - GPCRs
What does the adrenal medulla secrete
adrenaline into blood
Describe nicotinic receptors
always myelinated, cholinergic, ionotropic
How can drugs indirectly enhance cholinergic transmission
inhibit cholinesterase
What is the effect of inhibiting cholinesterase
ACh levels increase
How are anti-cholinesterase drugs classified
duration of action
Example of a short acting anti-cholinesterase dug
edrophonium
What is edrophonium used for
diagnosis of myasthenia gravis
What are medium length anti-cholinesterase drugs
neostigmine, pyridostigmine
What are neostigmine and pyridostigmine used for
myasthenia gravis
What is the function of physostigmine
crosses BBB, used for glaucoma
How do long acting anti-cholinesterase drugs work?
irreversible, cross BBB, bind to enzyme with covalent bond
What are the different subtypes of muscarinic receptors
Gq, Gi
What is the function of M1-Gq muscarinic receptor
regulates activity of phospholipase C, generates intracellular messengers