Respiration IV Flashcards

1
Q

Describe the inter pleural pressure compared to the base

A

inter pleural pressure is more negative at apex compared to base

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2
Q

Where is the apex of the lung

A

top of the lung

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3
Q

Why are pressures in the lung different

A

posture, gravity

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4
Q

Where is ventilation greater in the lung?

A

base

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5
Q

TRUE or FALSE - sub-atmospheric pressure is the same throughout the inter pleural space

A

FALSE

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6
Q

Where is the starting volume of alveoli bigger

A

top of lungs

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7
Q

What is the pressure of pulmonary circulation

A

low

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8
Q

Where is lung perfusion greater

A

base

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9
Q

What is daltons law

A

total pressure of a mixture of gases - sum of their individual partial pressures

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10
Q

What is the ventilation/perfusion ration

A

rate of alveolar ventilation and pulmonary blood flow

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11
Q

What does the ventilation ratio give an idea about

A

efficiency of gas exchange in particular regions of the lung

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12
Q

What do ventilation/perfusion mismatches show

A

problem with gas ventilation or blood perfusion

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13
Q

Describe the structure of adult haemoglobin

A

tetrameric - 2 alpha chains, 2 beta chains

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14
Q

Describe the haem unit

A

porphyrin ring containing a single iron atom

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15
Q

What enzyme converts Fe3+ into Fe2+

A

methaemoglobin reductase

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16
Q

What is the state of iron for haemoglobin to bind

A

Fe2+

17
Q

What are the two states of haemoglobin

A

tensed, relaxed

18
Q

What state has a low affinity for oxygen

A

tensed

19
Q

What state has a high affinity for oxygen

A

relaxed

20
Q

what is the state of haemoglobin at low oxygen concentrations

A

tense

21
Q

Which way does the oxygen haemoglobin curve shift in acidic conditions

A

to the right

22
Q

Which way does the oxygen haemoglobin curve shift when CO2 increases

A

to the right

23
Q

Which way does the oxygen haemoglobin curve shift in decrease of pH

A

to the right

24
Q

What way does the oxygen haemoglobin curve shift during active respiration

A

right

25
Q

What is the effect of temperature increase on the oxygen haemoglobin curve

A

shifts right

26
Q

What is the effect of CO2 decrease on oxygen haemoglobin curve

A

shifts left

27
Q

What is the effect of 2,3 DPG production increase on oxygen haemoglobin curve

A

shifts right

28
Q

What is the effect of shifting the oxygen haemoglobin curve to the RIGHT

A

decreased affinity for O2 on haemoglobin, more O2 released to tissue

29
Q

When is the oxygen haemoglobin curve required to shift to the right

A

active respiration

30
Q

Describe the structure of fetal haemoglobin

A

2 alpha, 2 gamma chains

31
Q

Describe oxygen- haemoglobin curve of fetal haemoglobin

A

shifts left

32
Q

What is the effect of shifting the oxygen-haemoglobin curve to the left

A

higher affinity for oxygen

33
Q

How does blood carry CO2

A

bicarbonate, carbonate, carbonic acid, carboamino compounds

34
Q

How is the majority of CO2 carried

A

bicarbonate dissolved in the plasma

35
Q

What is the plasma pH

A

7.4