CNS VII (MS)

Question 1

Age peak
F:M ratio

Answer 1

35y
2-3:1

Question 2

Key imaging modality for multiple sclerosis

Answer 2

MRI

Question 3

Definition of MS

Answer 3

It is the most common chronic inlfammatory demyelinating disease affecting the CNS of young adults

Question 4

MS leading in most cases to:

Answer 4

Severe and irreversible clinical disability

Question 5

Classification of MS according to its clinical presentation:

Answer 5

1. Relapsing-remitting (70% of cases)
2. 2ry progressive (85%)
3. 1ry progressive (10%)

Question 6

Applications of MRI in MS

Answer 6

• Earlies dx in combination with characteristics and symptoms.
• Understanding of the pathophysiology of MS
• Identify response to therapy in individual patients

Question 7

MRI sequences used in MS

Answer 7

T1/T1+C
T2
Flair

Question 8

MS on T1WI:

Answer 8

Lesions are typically iso to hypointense (black holes)

Question 9

MS on T2 and Flair

Answer 9

Lesions are typically hyperintense

Question 10

Flair is more sensitive than T2 in detection of:

Answer 10

Juxta-cortical and periventricular plaques

Question 11

T2 is more sensitive than flair in

Answer 11

Infra-tentorial lesion

Question 12

Signs of MS

Answer 12

Ependymal-dot
Dawson finger

Question 13

Ms on T1+C

Answer 13

Active lesions show enhancement (open ring sign)

Question 14

Other Advanced magnetic resonance techniques that my be used in MS

Answer 14

DWI (Diffusion-weighted image)

MRS (Magnetic resonance spectroscopy)

DIR (Double inversion recovery)