Chapter 8 - Immune System Toxicology Flashcards
The lymphoid precursor cell is derived from…
A. Null cell
B. Pluripotent stem cell
C. Myeloid precursor
D. Monocyte
B. Pluripotent stem cell
All of the following are components of tertiary lymphoid tissue except…
A. Spleen
B. Peyer’s patches
C. Skin-associated lymphoid tissue (SALT)
D. Nasal-associated lymphoid tissue (NALT)
A. Spleen
All of the following are considered nonself by the immune system except…
A. Cancers
B. Red blood cells
C. Bacteria
D. Viruses
B. Red blood cells
T cell precursors are programmed to leave the bone marrow and migrate to the…
A. Spleen
B. Lymph nodes
C. Thymus
D. Peyer’s patches
C. Thymus
Thymic education means that T cells…
A. Are converted to B cells
B. Are taught to recognize self vs non-self
C. Are taught to produce immunoglobulins
D. Are taught to proliferate rapidly
B. Are taught to recognize self vs non-self
Peyer’s patches are…
A. Collect antigens from the gastrointestinal tract
B. Are parts of the tonsillar tissue
C. Are located in the center of the spleen
D. Are located in the lung
A. Collect antigens from the gastrointestinal tract
Tertiary lymphoid tissue…
A. Produce totipotent stem cells
B. Include the thymus
C. Have direct contact with the external environment
D. All of the above
C. Have direct contact with the external environment
All of the following are parts of the innate immune system except…
A. Macrophages
B. B cells
C. NK cells
D. PMNs
B. B cells
All of the following are true of IgG except…
A. It crosses the placenta
B. There are subclasses
C. It can fix complement
D. It can degranulate mast cells
D. It can degranulate mast cells
All of the following are true of INFalpha except…
A. It is classified as an immunosuppressant
B. It is used to treat hepatitis C
C. It is asso w/ autoimmune disease
D. It has antiviral properties
A. It is classified as an immunosuppressant
All of the following are true of antigens except…
A. They are 10 kDa or larger
B. They are non-self substances that can be recognized by the immune system
C. Parts of the human body can never be antigens
D. They can be foreign DNA, RNA, protein or carbohydrates
C. Parts of the human body can never be antigens
The inability of self-reactive T cells that escape negative selection to proliferative in response to self-antigen exposure is called…
A. Autoimmunity
B. Self-tolerance
C. Hypersensitivity
D. Opsonization
B. Self-tolerance
All of the following statements are true regarding developmental immunology except…
A. Immune system development is complete at birth
B. The immune system develops from a population of pluripotent stem cells
C. Animals with short gestation periods have relatively immature immune systems at birth compared to humans
D. Exposure to specific antigens during the prenatal period allows the organism not to develop autoimmune reactions later in life.
A. Immune system development is complete at birth
All of the following are autoimmune diseases except…
A. Rheumatoid arthritis
B. multiple sclerosis
C. Schizophrenia
D. Myasthenia gravis
C. Schizophrenia
An assay that was developed to test the immunostimulating capacity of pharmaceuticals is…
A. ELISA
B. Flow cytometric analysis
C. Popliteal lymph node assay
D. All of the above
C. Popliteal lymph node assay
All of the following are direct mechanisms of xenobiotic-induced immune modulation except…
A. Increased mineralocorticoid release from adrenal gland
B. Altered antibody-mediated response
C. Altered cell-mediated response
D. Altered host resistance
A. Increased mineralocorticoid release from adrenal gland
A prolonged inflammatory response may contribute to the development of…
A. Alzheimer’s disease
B.Cardiovascular disease
C. Multiple Sclerosis
D. All of the above
D. All of the above
When a cytotoxic cell attaches to an Fc protein of IgG directed against a foreign antigen, the hypersensitivity rxn is called type…
A. I
B. II
C. III
D. IV
B. II
When IgG or IgM directed against soluble antigens produces antigen-antibody complexes that are deposited in tissues, the hypersensitivity rxn is called type…
A. I
B. II
C. III
D. IV
C. III
When an antigen processing cell interacts with T cells leading to the generation and proliferation of memory T cells, the hypersensitivity rxn is type…
A. I
B. II
C. III
D. IV
D. IV
The process of negative selection for self-reactive T cells occurs in the…
A. Bone marrow
B. Spleen
C. Thymus
D. Lymph nodes
C. Thymus
An essential component of antigen processing is…
A. Return of antigen-processing cell to bone marrow
B. a time interval of 7 days between internalization of antigen and its appearance on the cell surface
C. Binding of complement to antigen-processing cell
D. Asso. of modified antigen with major histocompatibility complex
D. Asso. of modified antigen with major histocompatibility complex
All of the following are true except…
A. Monocytes circulate in the blood for about a day
B. natural killer cells are derived from the monocyte
C. Perforin and granzyme are mediators of cell death by NK cells
D. PMNs combat microrganisms by the release of ROS
B. natural killer cells are derived from the monocyte
Mononuclear phagocytes within the CNS are called….
A. Microglia
B. Kupffer cells
C. Stellate cells
D. Astrocytes
A. Microglia