Chapter 11 - Renal Toxicology Flashcards
A toxicant transported to the kidney via the blood will haave the highest delivery rate to the renal…
A. Medulla
B. Cortex
C. Papilla
D. None of the above
B. Cortex
The kidney is involved in all of the following metabolic processes except…
A. Phase 1 biotransformation
B. synthesis of aldosterone
C. Synthesis of renin
D. Synthesis of erythropoietin
B. synthesis of aldosterone
Which of the following is least likely to pass through the glomerulus?
A. Polycationic molecules
B. inulin
C. Polyanionic macromolecules
D. Neutral macromolecules
C. Polyanionic macromolecules
The portion of the proximal tubule that is characterized by a tall brush border and a well developed vascular lysosomal system is…
A. S1
B. S2
C. S3
D. S4
A. S1
The portion of the proximal tubule that is noted for catabolism, high apical transport of glutathione, and high gamma-glutamyl transpeptidase is…
A. S1
B. S2
C. S3
D. S4
C. S3
Analgesic nephropathy is due to long-term use of the combination of…
A. NSAIDs and acetaminophen
B. acetaminophen and opiates
C. Opiates and NSAIDs
D. Tramadol and acetominophen
A. NSAIDs and acetaminophen
NSAID use is asso w/…
A. Renal allograph rejection
B. Interstitial nephritis
C. Renal cell carcinoma
D. All of the above
B. Interstitial nephritis
A process that plays a role in aminoglycoside proximal tubule nephrotoxicity is…
A. Deposition of immune complexes
B. Free radical formation
C. Decrease in cellular calcium
D. Phospholipidosis
D. Phospholipidosis
A process that plays a key role in the nephrotoxicity of halogenated hydrocarbons is…
A. Selective transport
B. tubular secretion
C. Renal vasoconstrictor
D. Biotransformation
D. Biotransformation
One mechanism for the renal toxicity of cyclosporin is thought to be increased production of…
A. Thromboxane
B. Vasodilatory prostaglandins
C. Endorphins
D. Aldosterone
A. Thromboxane
In the presence of superoxide, nitric oxide can be converted to which radical implicated in renal ischemia/reperfusion injury?
A. Nitric oxide radical
B. nitrogen anion
C. Peroxinitrite anion
D. Nitrogen dioxide anion
C. Peroxinitrite anion
If a nephrotoxicant’s primary mechanism of action is ATP depletion…
A. Apoptosis will dominate oncosis at all toxicant concentrations
B. Oncosis may be the main cause of death with limited apoptosis
C. Oncosis will never occur
D. None of the above
B. Oncosis may be the main cause of death with limited apoptosis
A test to measure renal blood flow in humans is…
A. Insulin clearance
B. creatine clearance
C. Serum cystatin C
D. None of the above
D. None of the above
Binding to renal sulfhydral groups is thought to play a role in the renal toxicity of…
A. Metals
B. fluoride ion
C. Aminoglycosides
D. Hydrogen sukfide
A. Metals
An increase in urinary excretions of alkaline phosphatase and gamma glutamyl transpeptidase suggests damage to…
A. Glomuerulus
B. Collecting duct
C. Afferent anteriole
D. Brush border
D. Brush border
A drug that interacts with sterols and causes the distal tubular epithelium to leak water and ions is…
A. Methoyflurane
B. Amphotericin B
C. Fentanyl
D. Acetominophen
B. Amphotericin B
A test to evaluate glucosuria in the presence of normal serum glucose would be…
A. Urine pH
B. 24 h excretion of albumin
C. 24 h excretion of B2 microglobulin
D. Urine creatinine
C. 24 h excretion of B2 microglobulin
A characteristic of renal glomerular injury is…
A. Albuminuria
B. White cell casts
C. Uric acid crystals on urinanalysis
D. Amino acids in the urine
A. Albuminuria