Chapter 10 - Hepatic Toxicology Flashcards
The liver is the first organ to encounter all of the following except…
A. Waste products of gut bacteria
B. Inhaled gases
C. Ingested metals
D. Oral drugs
B. Inhaled gases
Early stages of ethanol abuse are chara by…
A. Inability to degrade lipids
B. Inability to transport lipids out of the liver
C. Increased lipid synthesis
D. All of the above
B. Inability to transport lipids out of the liver
Zone 3 of the hepatic acinus is characterized by…
A. High bile acid conc.
B. Relative hypoxia
C. Proximity to the portal vein
D. Proximity to the hepatic artery
B. Relative hypoxia
Zone 1 of the hepatic acinus is chara by…
A. High levels of GSH
B. Higher levels of P450
C. Prox to hepatic vein
D. Low bile acid extraction
A. High levels of GSH
CYP 2E1 is highest in acinus zone…
A. 1
B. 2
C. 3
D. 4
C. 3
Decreased protein synthesis by the liver would cause all of the following conditions except…
A. Ascites
B. hypoglycemia
C. Bleeding
D. Increased free fraction of drug
C. Bleeding
All of the following are components of bile except…
A. Glutathione
B. cholesterol
C. Uric acid
D. Bilirubin
C. Uric acid
Bile acid formation plays a key role in all of the following except…
A. The innate immune system
B. Excretion of endogenous cmpds
C. Uptake of lipid nutrients from sm intestine
D. Protection of the sm intestine from ox stress
A. The innate immune system
Rats lacking functional MRP2 biliary exporter would be resistant to…
A. Fibrosis from EtOH
B. Intestinal ulceration from diclofenac
C. Carcinogenicity of androgens
D. Fatty liver from tamoxifen
B. Intestinal ulceration from diclofenac
A major site for vitamin A storage is…
A. Hepatocyte
B. cholangiocyte
C. Kupffer cell
D. Stellate cell
D. Stellate cell
Hepatic sinusoids are lined with all of the following except…
A. Stellate cells
B. Endothelial cells
C. Kupffer cells
D. Enterocytes
D. Enterocytes
All of the following are true of hepatic fenestrae except…
A. Molecules smaller than 250 kDa can cross
B. albumin can cross
C. The space between hepatocytes and endothelium is called the space of Disse
D. They are similar to pores in skeletal muscle
B. albumin can cross
Which of the following statements is true?
A. The liver cannot regenerate
B. Methylmercury is reabsorbed from the gallbladder
C. Zn toxicity is manifested by cholestasis
D. All of the above
B. Methylmercury is reabsorbed from the gallbladder
A transport pump that moves chemicals from hepatocytes into bile caniculi is…
A. OAT
B. BSEP
C. OCT
D. all of the above
B. BSEP
Which of the following statements is true?
A. Arsenic is enterohepatically recirculated
B. Microcystin disrupts the hepatic cytoskeleton
C. Billary epithelial cells possess biotransformation enzymes
D. All of the above
D. All of the above
The most common cause of fatty liver is…
A. Valproic acid
B. fialuridine
C. Insulin resistance
D. CCL4
C. Insulin resistance
All of the following statements are true regarding steatosis and steatohepatitis except…
A. Cyclohexamide causes fat accum. and cell necrosis
B. Steatohepatitis can progress to fibrosis
C. The presence of steatosis can make the liver more sensitive to other insults
D. Steatohepititis can progress to hepatocellular carcinoma
A. Cyclohexamide causes fat accum. and cell necrosis
Dilation of the hepatic sinusoid or peliosis hepatis is caused by…
A. Aminodarone
B. danazol
C. Tetracycline
D. Halothane
B. danazol
Vanishing bile duct syndrome is asso w/ all of the following except…
A. Ethanol
B. carbamazepine
C. Anabolic steroids
D. Contraceptive steroids
A. Ethanol
All of the following have been shown to inhibit the bile salt export pump (BSEP) except…
A. Rifampicin
B. Bosentan
C. Troglitazone
D. Acetominophen
D. Acetominophen
In the liver, the difference between oncotic necrosis and secondary necrosis is…
A. Cell swelling
B. Cell content release
C. Identification of apoptotic cells
D. None of the above
C. Identification of apoptotic cells
A pancaspase inhibitor would be expected to…
A. Prevent apoptosis-induced liver injury
B. induce oncotic liver injury
C. Deplete cellular ATP by damaging the mitochondrial membrane
D. None of the above
A. Prevent apoptosis-induced liver injury
Vitamin C causes…
A. Fatty liver
B. canalicular cholestasis
C. Bile duct damage
D. None of the above
D. None of the above