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Repro > Causes of precocious puberty > Flashcards

Causes of precocious puberty Flashcards

1
Q

what are the 2 main causes of precocious puberty?

A 
gonadotrophin dependent (central)
gonadotrophin independent (neurological)
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2
Q

what are causes of gonadotrophin dependent (central) causes of precocious puberty?

A
  1. hormone secreting tumours
  2. CNS trauma
  3. congenital
  4. gonadotrophin secreting tumours
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3
Q

what are hormone secreting tumours causing gonadotrophin dependent (central) precocious puberty?

A

hCG,
pineal tumour,
gliomas,
astrocytomas

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4
Q

what are CNS traumas causing gonadotrophin dependent (central) precocious puberty?

A

radiation,
surgery,
infection (meningitis)

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5
Q

what are congenital causes of gonadotrophin dependent (central) precocious puberty?

A

hydrocephalus,

arachnoid cyst

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6
Q

what does gonadotrophin independent causes lead to precocious puberty (neurological)?

A

increase testosterone & oestrogen: suppresses FSH/LH

early stimulation of central maturation: increase steroid hormone production INDEPENDENT of hypothalamus GnRH

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7
Q

what are gonadotrophin independent causes of precocious puberty (neurological)?

A

pineal tumours
congenital adrenal hyperplasia (excess androgens)
testotoxicosis
ovarian tumour / Leydig cell tumour

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8
Q

symptoms of testotoxicosis?

A 
Premature male puberty
Aggressiveness (2-3 years)
Reduced adult stature
Premature voice deepening
Premature armpit hair growth
Tall for age child
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9
Q

what does congenital adrenal hyperplasia cause in males?

A

enlarged penis

masculinising hormone

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10
Q

causes of delayed puberty?

A
  1. long-term illness
  2. malnutrition
  3. problem with ovaries, testes, thyroid gland, pituitary gland
  4. disorder of sexual development: androgen insensitivity syndrome
  5. genetic
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11
Q

what are long term illness’ causing delayed puberty?

A

CF, diabetes or kidney disease

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12
Q

what are malnutrition / weight problems causing delayed puberty?

A

critical weight of 47kg (F) / 55kg (M) not reached
eating disorder / CF / coeliac disease
lean athletes

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13
Q

what are genetic causes of delayed puberty?

A

Kallman and Klinefelter syndrome

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14
Q

what is Klinefelter syndrome?

A

boys have 47, XXY

increased circulating oestrogen

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15
Q

what causes Kallman syndrome?

A

failure of the hypothalamus to release GnRH at the appropriate time as a result of the GnRH-releasing neurons not migrating into the correct location during embryonic development

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16
Q

how does Kallman syndrome present?

A

failure to start or a failure to complete puberty

accompanied by a lack of sense of smell (anosmia) or a highly reduced sense of smell (hyposmia)

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