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Therio - RUSS > Canine Pharmaceuticals > Flashcards

Canine Pharmaceuticals Flashcards

1
Q

Split Estrus: Presents as…:

A

short interval between clinical signs of proestrus

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2
Q

Ovaban - Megestrol Acetate:

Progestin - Approved for use in bitches or queens?

A

bitches only. caused diabetes mellitus in queens.

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3
Q

Ovaban - Megestrol Acetate:

dosing schedule?

A

daily dosing

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4
Q

Ovaban - Megestrol Acetate:

dosing/schedule for proestrus:

A

1 mg/lb PO every 8 days. Must be started in first 3 days of proestrus to be effective.

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5
Q

Ovaban - Megestrol Acetate:

Has what effect if given in proestrus?

A

Next cycle will be 4-6 weeks earlier

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6
Q

Side Effects of Progesterone adminstration:

Predisposes to :
1.
2.

A
  1. CEH

2. Pyometra

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7
Q

Progesterone needs to be in the ___ ng/mL or lower range to consider supplementing

A

3

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8
Q

Administer Prometrium through what method?

(decrease/increase) the dose as you get close to whelping

A
  1. orally

2. taper

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9
Q

Use Regumate (early/later) in pregnancy?

Why use it?

A

later.

Allows you to measure P4 to see if hypoluteoidism is real or not

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10
Q

Supplemental progesterone:

Ideally given when?

Why?

A

After 45 days of pregnancy or avoid first trimester minimally .

To avoid masculinization of female pups

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11
Q

Remove progesterone 2-3 days prior to due date = Why?

A

to allow cervix to relax adequately

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12
Q

Mibolerone - What kind of drug?

A

androgenic contraceptive

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13
Q

Mibolerone:

How does it work?

A

prevents LH release by negative feedback, thereby preventing estrus

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14
Q

Mibolerone:

contraindicated in what species? why?

not approved for use in what dogs?

A

Cats –> liver toxicity

Breeding Bitches

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15
Q

Mibolerone:

Dosing/administration schedule?

A

daily oral dosing started 30 days prior to next anticipated cycle

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16
Q

Mibolerone:

Side effects:
1.
2.
3.

A
  1. clitoral hypertrophy
  2. vaginitis
  3. lowered fertility of next heat
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17
Q

Mibolerone:

Approved for a maximum of how long?

A

24 months

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18
Q

Mibolerone:

Used in bitches with…

Why?

A

short interestrus intervals.

because short IEI may lead to infertility, early embryonic death, or small litter size

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19
Q

Testosterone

  1. used occasionally in what animals?
  2. Usually started when?
  3. Side effects?
A
  1. racing greyhounds
  2. Pre-puberty
  3. minimal
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20
Q

Deslorelin - GnRH analogue

(short/long)-acting?

A

a long acting implant

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21
Q

Deslorelin - GnRH analogue

How it works?

A

down-regulates putiutary-gonadal axis

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22
Q

Deslorelin - GnRH analogue

Advantages?

A

Safe and reversible

23
Q

Deslorelin - GnRH analogue

Purpose of using it?

A

suppression of repro function of dogs in situations where a reduced testosterone level is required, such as controlling antisocial behavior and treating prostatic enlargement.

24
Q

“Mismating” Shots:

Giving a shot of _____ within 72 hours of breeding.

25
"Mismating" Shots: Causes....
"tubular lockage" and disrupts/alters uterine environment
26
"Mismating" Shots: Side effect?
25% get pyometra
27
Estrogen Toxicity: Can cause _____ Clinical significance?
bone marrow suppression lethal and irreversible
28
Estrogen Toxicity: Prevent by....
not repeating ECP (Estradiol cypionate) injections more frequently than once every 30 days
29
Alternatives to "Mismating shots" 1. 2. 3.
1. Spaying once in diestrus 2. Waiting until Day 28-30, than aborting 3. Allowing whelping, followed by euthanasia of pups
30
Antiprogestins 1. How they work?
bind to progesterone receptors
31
Antiprogestins Main animal product one? Can be used as an...
Aglepristone early mismating shot
32
Multiple small injections of Prostaglandin will have what desired effect?
lyse the CL of bitch or queen.
33
Multiple small injections of Prostaglandin will have what side effect?
smooth muscle contractions that minimize over time, drops in BP, vomiting, diarrhea, salivation, panting
34
Prostaglandin injections: ``` Used to treat: 1. 2. 3. 4. to assist in... ```
1. pyometra 2. retained placenta 3. mismating shots 4. collection of males
35
Prolactin Inhibitors: 1. 2.
1. Bromocriptine - Dopamine Agonist | 2. Cabergoline - Serotonin antagonist
36
Prolactin Inhibitors: Effect? Use when?
luteotropic = lyses CL's During 2nd trimester
37
Abortion Induction: Use what drug if before gestation?
Lutalyse
38
Abortion Induction: Use what drug if after mid-gestation?
Bromocryptine plus lutalyse
39
Bromocryptine plus lutalyse as mid-gestation abortion induction: Advantage over Cabergoline?
less expensive
40
Bromocryptine plus lutalyse as mid-gestation abortion induction: After dosing, do what to the bitch?
walk her, to avoid side effects from prostaglandin
41
Bromocryptine plus lutalyse as mid-gestation abortion induction: takes how many doses before abortion is complete?
10-12 doses
42
Estrus induction: When would you want to do it?
When bitch does not come back into estrus for a prolonged period.
43
Estrus induction: Use what drug?
Cabergoline (serotonin antagonist).
44
Estrus induction with Cabergoline: ___% will induce within 14 days
70%
45
Estrus induction with Cabergoline: Make sure low ___ before start.
P4
46
Canine Psuedopregnancy: Definition
syndrome of mammary development, galactorrhea, nesting behavior, mothering behavior
47
Canine Psuedopregnancy: Normal in dogs when?
after estrus in bitches
48
Canine Psuedopregnancy: Happens when in queens?
ONLY after theyve been stimulated to ovulate
49
Canine Psuedopregnancy: Treatment: 1. 2.
1. Cabergoline | 2. Time (self limiting)
50
Unwanted uterine contractions: Often dogs on...
Whelpwise
51
Unwanted uterine contractions: 1. Best treatment? 2. Less effective tx?
1. Terbutaline - a Beta 2 agonist | 2. Progesterone
52
Unwanted uterine contractions: Side effects of high terbutaline dosages?
cardiac effects
53
Unwanted uterine contractions: Look for what as causes of abnormal contractions? 1. 2. 3.
1. Dead pup 2. infection 3. inflam
54
Domperidone Used for bitch that...
whelps with little to no milk

Therio - RUSS (23 decks)

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