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Therio - RUSS > Canine Pharmaceuticals > Flashcards

Canine Pharmaceuticals Flashcards

1
Q

Split Estrus: Presents as…:

A

short interval between clinical signs of proestrus

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2
Q

Ovaban - Megestrol Acetate:

Progestin - Approved for use in bitches or queens?

A

bitches only. caused diabetes mellitus in queens.

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3
Q

Ovaban - Megestrol Acetate:

dosing schedule?

A

daily dosing

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4
Q

Ovaban - Megestrol Acetate:

dosing/schedule for proestrus:

A

1 mg/lb PO every 8 days. Must be started in first 3 days of proestrus to be effective.

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5
Q

Ovaban - Megestrol Acetate:

Has what effect if given in proestrus?

A

Next cycle will be 4-6 weeks earlier

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6
Q

Side Effects of Progesterone adminstration:

Predisposes to :
1.
2.

A
  1. CEH

2. Pyometra

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7
Q

Progesterone needs to be in the ___ ng/mL or lower range to consider supplementing

A

3

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8
Q

Administer Prometrium through what method?

(decrease/increase) the dose as you get close to whelping

A
  1. orally

2. taper

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9
Q

Use Regumate (early/later) in pregnancy?

Why use it?

A

later.

Allows you to measure P4 to see if hypoluteoidism is real or not

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10
Q

Supplemental progesterone:

Ideally given when?

Why?

A

After 45 days of pregnancy or avoid first trimester minimally .

To avoid masculinization of female pups

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11
Q

Remove progesterone 2-3 days prior to due date = Why?

A

to allow cervix to relax adequately

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12
Q

Mibolerone - What kind of drug?

A

androgenic contraceptive

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13
Q

Mibolerone:

How does it work?

A

prevents LH release by negative feedback, thereby preventing estrus

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14
Q

Mibolerone:

contraindicated in what species? why?

not approved for use in what dogs?

A

Cats –> liver toxicity

Breeding Bitches

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15
Q

Mibolerone:

Dosing/administration schedule?

A

daily oral dosing started 30 days prior to next anticipated cycle

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16
Q

Mibolerone:

Side effects:
1.
2.
3.

A
  1. clitoral hypertrophy
  2. vaginitis
  3. lowered fertility of next heat
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17
Q

Mibolerone:

Approved for a maximum of how long?

A

24 months

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18
Q

Mibolerone:

Used in bitches with…

Why?

A

short interestrus intervals.

because short IEI may lead to infertility, early embryonic death, or small litter size

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19
Q

Testosterone

  1. used occasionally in what animals?
  2. Usually started when?
  3. Side effects?
A
  1. racing greyhounds
  2. Pre-puberty
  3. minimal
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20
Q

Deslorelin - GnRH analogue

(short/long)-acting?

A

a long acting implant

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21
Q

Deslorelin - GnRH analogue

How it works?

A

down-regulates putiutary-gonadal axis

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22
Q

Deslorelin - GnRH analogue

Advantages?

A

Safe and reversible

23
Q

Deslorelin - GnRH analogue

Purpose of using it?

A

suppression of repro function of dogs in situations where a reduced testosterone level is required, such as controlling antisocial behavior and treating prostatic enlargement.

24
Q

“Mismating” Shots:

Giving a shot of _____ within 72 hours of breeding.

A

estrogen.

25
Q

“Mismating” Shots:

Causes….

A

“tubular lockage” and disrupts/alters uterine environment

26
Q

“Mismating” Shots:

Side effect?

A

25% get pyometra

27
Q

Estrogen Toxicity:

Can cause _____

Clinical significance?

A

bone marrow suppression

lethal and irreversible

28
Q

Estrogen Toxicity:

Prevent by….

A

not repeating ECP (Estradiol cypionate) injections more frequently than once every 30 days

29
Q

Alternatives to “Mismating shots”

1.
2.
3.

A
  1. Spaying once in diestrus
  2. Waiting until Day 28-30, than aborting
  3. Allowing whelping, followed by euthanasia of pups
30
Q

Antiprogestins

  1. How they work?
A

bind to progesterone receptors

31
Q

Antiprogestins

Main animal product one?
Can be used as an…

A

Aglepristone

early mismating shot

32
Q

Multiple small injections of Prostaglandin will have what desired effect?

A

lyse the CL of bitch or queen.

33
Q

Multiple small injections of Prostaglandin will have what side effect?

A

smooth muscle contractions that minimize over time, drops in BP, vomiting, diarrhea, salivation, panting

34
Q

Prostaglandin injections:

Used to treat:
1.
2.
3.
4. to assist in...
A
  1. pyometra
  2. retained placenta
  3. mismating shots
  4. collection of males
35
Q

Prolactin Inhibitors:

1.
2.

A
  1. Bromocriptine - Dopamine Agonist

2. Cabergoline - Serotonin antagonist

36
Q

Prolactin Inhibitors:

Effect? Use when?

A

luteotropic = lyses CL’s

During 2nd trimester

37
Q

Abortion Induction:

Use what drug if before gestation?

A

Lutalyse

38
Q

Abortion Induction:

Use what drug if after mid-gestation?

A

Bromocryptine plus lutalyse

39
Q

Bromocryptine plus lutalyse as mid-gestation abortion induction:

Advantage over Cabergoline?

A

less expensive

40
Q

Bromocryptine plus lutalyse as mid-gestation abortion induction:

After dosing, do what to the bitch?

A

walk her, to avoid side effects from prostaglandin

41
Q

Bromocryptine plus lutalyse as mid-gestation abortion induction:

takes how many doses before abortion is complete?

A

10-12 doses

42
Q

Estrus induction:

When would you want to do it?

A

When bitch does not come back into estrus for a prolonged period.

43
Q

Estrus induction:

Use what drug?

A

Cabergoline (serotonin antagonist).

44
Q

Estrus induction with Cabergoline:

___% will induce within 14 days

A

70%

45
Q

Estrus induction with Cabergoline:

Make sure low ___ before start.

A

P4

46
Q

Canine Psuedopregnancy:

Definition

A

syndrome of mammary development, galactorrhea, nesting behavior, mothering behavior

47
Q

Canine Psuedopregnancy:

Normal in dogs when?

A

after estrus in bitches

48
Q

Canine Psuedopregnancy:

Happens when in queens?

A

ONLY after theyve been stimulated to ovulate

49
Q

Canine Psuedopregnancy:

Treatment:
1.
2.

A
  1. Cabergoline

2. Time (self limiting)

50
Q

Unwanted uterine contractions:

Often dogs on…

A

Whelpwise

51
Q

Unwanted uterine contractions:

  1. Best treatment?
  2. Less effective tx?
A
  1. Terbutaline - a Beta 2 agonist

2. Progesterone

52
Q

Unwanted uterine contractions:

Side effects of high terbutaline dosages?

A

cardiac effects

53
Q

Unwanted uterine contractions:

Look for what as causes of abnormal contractions?
1.
2.
3.

A
  1. Dead pup
  2. infection
  3. inflam
54
Q

Domperidone

Used for bitch that…

A

whelps with little to no milk

Therio - RUSS (23 decks)

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