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Microbiology > Bartonella & Rickettsiales 1 & 2 > Flashcards

Bartonella & Rickettsiales 1 & 2 Flashcards

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Biology 101 flashcards
1
Q

what cell type is Bartonella facultative intracellular for?

A

endothelial cells and erythrocytes

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2
Q

what population does Bartonella cause disease in?

A

accidental host
reservoir host animals in poor health (immunodeficient)

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3
Q

Describe the media and growth of Bartonella

A

blood-enriched media (ex. chocolate agar) , slow growth

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4
Q

Describe the lesions of Bartonella

A
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5
Q

what disease dose Bartonella henselae cause and in what reservoir?

A

endorcarditis in felids

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6
Q

what is the primary disease caused by Bartonella bacteria?

A

endocarditis

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7
Q

what is the vector of Bartonella henselae?

A

cat flea

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8
Q

what bacteria caused these lesions?

A

Bartonella

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9
Q

what bacteria caused these lesions?

A

Bartonella

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10
Q

what is shown in this image?

A
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11
Q

How is Bartonella presumptively diagnosed?

A

clinical presentation + exposure to biting arthropods

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12
Q

How does bartonella get a confirmatory diagnosis?

A

culture, PCR, MALDI-TOF

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13
Q

How is Bartonella treated?

A

antimicrobials - only clinical signs or asymptomatic living with immunocompromised
doxycycline, azithromycin, enrofloxacin

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14
Q

How are Bartonella infections controlled?

A

limit exposure to vectors

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15
Q

What type of disease does rickettsiales cause?

A

athropod-borne diseases

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16
Q

Are Rickettsiales facultative intracellular or obligate intracellular?

A

obligate intracellular

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17
Q

What is the important reservoir hosts of Rickettsiales?

A

ticks

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18
Q

Who are the accidental hosts of Rickettsiales?

A

humans

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19
Q

What Rickettsiales causes the following -
Rickettsioses
Anaplasmoses
Ehrlichoises
Neorickettsioes

A

Rickettsioses - Rickettsia spp.
Anaplasmoses - Anaplasma spp.
Ehrlichoises - Ehrlichia spp.
Neorickettsioes - Neorickettsia spp.

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20
Q

Describe the pathogenesis of Rickettsiaceae

A

invade & grow in endothelial cells of small blood vessels > necrotizing vasculitis > increased vascular permeability > edema, hemorrhage, hypovolemia > encephalitis, nephritis, myocarditis

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21
Q

what is the causative agent of Rocky mountain spotted fever?

A

Rickettsia rickettsii

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22
Q

what is the host/vector of RMSF in the USA?

A

ticks

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23
Q

How is Rickettsia rickettsii transmitted in ticks?

A

transovarial

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24
Q

How does RMSF present in dogs?

A
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25
Q

How is R. rickettsii diagnosed?

A

presumptive - presentation, exposure to ticks in RMSF endemic areas
confirmatory - serology, PCR

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26
Q

How do you treat RMSF and when?

A

doxycycline or tetracycline
do not delay for confirmatory lab results

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27
Q

How is RMSF controlled?

A

limit exposure to potentially infected ticks

28
Q

In the arizona tribal RMSF response plan what is there an emphasis on?

A

brown dog tick surveillance and control

29
Q

What cells does Anaplasmataceae infect? where do they multiply?

A

hematopoietic origin
multiple within membrane-bound structures called morulae

30
Q

What cells does A. marginale infect?

A

RBCs of ruminants

31
Q

what cells does A. platys infect?

A

platelets, primarily of canids
only infectious agent known to replicate in platelets

32
Q

what cells does A. phagocytophilum infect?

A

granulocytes of diverse mammals

33
Q

what is the most prevalent tick-borne disease of cattle and what is the causative agent?

A

bovine anaplasmosis
Anaplasma marginale

34
Q

How is A. marginale diagnosed in cattle?

A

presumptive - clinical signs, inclusion bodes (morulae) near margin of stained RBCs
definitive - serology, PCR

35
Q

what ages of cattle are most affected by Anaplasma marginale?

A
36
Q

what is significant about survivors of Bovine anaplasmosis?

A

chronic, lifelong, subclinical infections - carrier state

37
Q

what is used to treat A. marginale in cattle?

A

tetracyclines

38
Q

what is the causative agent of Infectious canine cyclic thrombocytopenia?

A

A. platys

39
Q

what is a key clinical sign of infectious canine cyclic thrombocytopenia?

A

epistaxis

40
Q

How is A. platys diagnosed in ICCT?

A

clinical signs, hx tick exposure, morulae in stained platelets
snap 4dx

41
Q

How is A. platys treated in dogs?

A

doxycycline

42
Q

what bacteria is causing this morulae formation?

A

A. platys
in platelets

43
Q

what bacteria is causing this morulae formation?

A

A. marginale
in RBCS near margins

44
Q

what type of cell does A. phagocytophilum infect?

A

primarily granulocytes

45
Q

what is a common clinical sign of canine granulocytic anaplasmosis?

A

lameness (polyarthritis)

46
Q

what animals does A. phagocytophilum infect?

A

canine - canine granulocytic anaplasmosis
equine - equine granulocytic anaplasmosis
ruminants - tick-borne fever, not in USA

47
Q

what is the causative agent in this infection? blacklegged ticks on patient

A

A. phagocytophilum morula in neutrophil

48
Q

what is the causative agent of canine monocytic ehrlichiosis?

A

E. canis

49
Q

what is the causative agent of canine granulocytic ehrlichiosis?

A

E. ewingii

50
Q

what des E. chaffeenis cause?

A

unnamed ehrlichiosis in dogs

51
Q

what types of cells does E. canis have a tropism for?

A

monocytes and macrophages

52
Q

what is the causative agent - brown dog tick found on dog

A

acute E. canis

53
Q

what form of E. canis is fatal?

A

chronic canine monocytic ehrlichiosis

54
Q

which tick transmits Anaphasma phagocytophilum?

A

blacklegged ticks

55
Q

what cell does E. ewingii have a tropism for?

A

granulocytes

56
Q

what is the causative agent in this infection? brown dog ticks on patient

A
57
Q

what cell does E. chaffeenis have a tropism for?

A

monocytes

58
Q

what is the causative agent?

A

E. chaffeensis
could also be E. canis since they infect monocytes & macrophages

59
Q

what bacteria are obligate intracellular symbionts of flukes?

A

Neorickettsia

60
Q

what is the causative agent of salmon poisoning disease?

A

N. helminthoeca

61
Q

what is the causative agent of potomac horse fever?

A

N. risticii

62
Q

Describe the pathogenesis of salmon poisoning disease

A

dog eats fish infected with encysted fluke larvae > N. helminthoeca released by adult flukes > infected dog

63
Q

what is the causative agent? Dog just went on a fishing trip with owner

A

N. helminthoeca primarily infects monocytes and macrophages

64
Q

Describe the pathogenesis of N. risticii

A

horse eats adult mayfly/caddisfly infected with larval flukes > larvae do not mature in horse but release N. risticci > infects horse

65
Q

List the Neorickettsia that is released by adult flukes and larvae

A

adult - N. helminthoeca
larvae - N. risticii

65
Q

what is the causative agent of potomac horse fever?

A

N. risticii

Microbiology (29 decks)

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