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Microbiology > Bartonella & Rickettsiales 1 & 2 > Flashcards

Bartonella & Rickettsiales 1 & 2 Flashcards

1
Q

what cell type is Bartonella facultative intracellular for?

A

endothelial cells and erythrocytes

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2
Q

what population does Bartonella cause disease in?

A

accidental host
reservoir host animals in poor health (immunodeficient)

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3
Q

Describe the media and growth of Bartonella

A

blood-enriched media (ex. chocolate agar) , slow growth

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4
Q

Describe the lesions of Bartonella

A
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5
Q

what disease dose Bartonella henselae cause and in what reservoir?

A

endorcarditis in felids

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6
Q

what is the primary disease caused by Bartonella bacteria?

A

endocarditis

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7
Q

what is the vector of Bartonella henselae?

A

cat flea

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8
Q

what bacteria caused these lesions?

A

Bartonella

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9
Q

what bacteria caused these lesions?

A

Bartonella

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10
Q

what is shown in this image?

A
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11
Q

How is Bartonella presumptively diagnosed?

A

clinical presentation + exposure to biting arthropods

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12
Q

How does bartonella get a confirmatory diagnosis?

A

culture, PCR, MALDI-TOF

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13
Q

How is Bartonella treated?

A

antimicrobials - only clinical signs or asymptomatic living with immunocompromised
doxycycline, azithromycin, enrofloxacin

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14
Q

How are Bartonella infections controlled?

A

limit exposure to vectors

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15
Q

What type of disease does rickettsiales cause?

A

athropod-borne diseases

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16
Q

Are Rickettsiales facultative intracellular or obligate intracellular?

A

obligate intracellular

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17
Q

What is the important reservoir hosts of Rickettsiales?

A

ticks

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18
Q

Who are the accidental hosts of Rickettsiales?

A

humans

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19
Q

What Rickettsiales causes the following -
Rickettsioses
Anaplasmoses
Ehrlichoises
Neorickettsioes

A

Rickettsioses - Rickettsia spp.
Anaplasmoses - Anaplasma spp.
Ehrlichoises - Ehrlichia spp.
Neorickettsioes - Neorickettsia spp.

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20
Q

Describe the pathogenesis of Rickettsiaceae

A

invade & grow in endothelial cells of small blood vessels > necrotizing vasculitis > increased vascular permeability > edema, hemorrhage, hypovolemia > encephalitis, nephritis, myocarditis

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21
Q

what is the causative agent of Rocky mountain spotted fever?

A

Rickettsia rickettsii

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22
Q

what is the host/vector of RMSF in the USA?

A

ticks

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23
Q

How is Rickettsia rickettsii transmitted in ticks?

A

transovarial

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24
Q

How does RMSF present in dogs?

A
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25
How is R. rickettsii diagnosed?
presumptive - presentation, exposure to ticks in RMSF endemic areas confirmatory - serology, PCR
26
How do you treat RMSF and when?
doxycycline or tetracycline **do not delay for confirmatory lab results**
27
How is RMSF controlled?
limit exposure to potentially infected ticks
28
In the arizona tribal RMSF response plan what is there an emphasis on?
brown dog tick surveillance and control
29
What cells does Anaplasmataceae infect? where do they multiply?
hematopoietic origin multiple within membrane-bound structures called morulae
30
What cells does A. marginale infect?
RBCs of ruminants
31
what cells does A. platys infect?
platelets, primarily of canids **only infectious agent known to replicate in platelets**
32
what cells does A. phagocytophilum infect?
granulocytes of diverse mammals
33
what is the most prevalent tick-borne disease of cattle and what is the causative agent?
bovine anaplasmosis Anaplasma marginale
34
How is A. marginale diagnosed in cattle?
presumptive - clinical signs, **inclusion bodes (morulae)** near margin of stained RBCs definitive - serology, PCR
35
what ages of cattle are most affected by Anaplasma marginale?
36
what is significant about survivors of Bovine anaplasmosis?
chronic, lifelong, subclinical infections - **carrier state**
37
what is used to treat A. marginale in cattle?
tetracyclines
38
what is the causative agent of Infectious canine cyclic thrombocytopenia?
A. platys
39
what is a key clinical sign of infectious canine cyclic thrombocytopenia?
epistaxis
40
How is A. platys diagnosed in ICCT?
clinical signs, hx tick exposure, **morulae in stained platelets** snap 4dx
41
How is A. platys treated in dogs?
doxycycline
42
what bacteria is causing this morulae formation?
A. platys in platelets
43
what bacteria is causing this morulae formation?
A. marginale in RBCS near margins
44
what type of cell does A. phagocytophilum infect?
primarily granulocytes
45
what is a common clinical sign of canine granulocytic anaplasmosis?
lameness (polyarthritis)
46
what animals does A. phagocytophilum infect?
canine - canine granulocytic anaplasmosis equine - equine granulocytic anaplasmosis ruminants - tick-borne fever, not in USA
47
what is the causative agent in this infection? blacklegged ticks on patient
A. phagocytophilum morula in neutrophil
48
what is the causative agent of canine monocytic ehrlichiosis?
E. canis
49
what is the causative agent of canine granulocytic ehrlichiosis?
E. ewingii
50
what des E. chaffeenis cause?
unnamed ehrlichiosis in dogs
51
what types of cells does E. canis have a tropism for?
monocytes and macrophages
52
what is the causative agent - brown dog tick found on dog
acute E. canis
53
what form of E. canis is fatal?
chronic canine monocytic ehrlichiosis
54
which tick transmits Anaphasma phagocytophilum?
blacklegged ticks
55
what cell does E. ewingii have a tropism for?
granulocytes
56
what is the causative agent in this infection? brown dog ticks on patient
57
what cell does E. chaffeenis have a tropism for?
monocytes
58
what is the causative agent?
E. chaffeensis could also be E. canis since they infect monocytes & macrophages
59
what bacteria are obligate intracellular symbionts of flukes?
Neorickettsia
60
what is the causative agent of salmon poisoning disease?
N. helminthoeca
61
what is the causative agent of potomac horse fever?
N. risticii
62
Describe the pathogenesis of salmon poisoning disease
dog eats fish infected with encysted fluke larvae > N. helminthoeca released by adult flukes > infected dog
63
what is the causative agent? Dog just went on a fishing trip with owner
N. helminthoeca primarily infects monocytes and macrophages
64
Describe the pathogenesis of N. risticii
horse eats adult mayfly/caddisfly infected with larval flukes > larvae do not mature in horse but release N. risticci > infects horse
65
List the Neorickettsia that is released by adult flukes and larvae
adult - N. helminthoeca larvae - N. risticii
65
what is the causative agent of potomac horse fever?
N. risticii

Microbiology (29 decks)

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