B4 pt 1 Flashcards
What happens when we grow
When we grow our cells need to divide in order to make new cells. These stem cells need to specialise into different types of cells as stem cells are unspecialised
What is mitosis for
Growth and repair of cells
What is meiosis for
Used to make sex cells (gametes)
What is interphase?
Between cell divisions, all cells undergo interphase. During interphase, the cell still carries out the function of the cell that is dividing.
G1 phase
Cellular contents, excluding the chromosomes, are duplicated. For the organelles to duplicate, a lot of protein is required. Transcription and translation is the body’s way of making proteins so we can duplicate our organelles. Also, the size of the cell increases. This is to make sure that the daughter are the correct size after duplication.
S phase (synthesis)
Each of the 46 chromosomes is duplicated by the cell. DNA synthesis occurs and DNA is used to duplicate the chromosomes
G2 phase
The cell double checks the duplicated chromosomes for error, making any needed repair. Transcription and translation also occurs to repair any damaged chromosomes and replace the energy stores used in the S phase. The size of the cell increases to make sure that the daughter cells are the correct size after duplication
Mitotic phase
This is the phase where the cell splits in 2. Firstly, mitosis is where the chromosomes split into 2 separate nuclei within the same cell. Cytokinesis is where the cell divides into 2, each with one nuclei.
The 3 checkpoints
G1 checkpoint
G2 Checkpoint
Metaphase/spindle checkpoint
G1 checkpoint
This takes place before the S Phase and checks for 2 things:
1-There is a check to make sure that the cell has grown to the correct size
2-There is a check to see if there is any damaged DNA
G2 checkpoint
This takes place at the end of G2 and before the mitotic phase and also checks 2 things:
1-There is a check to make sure that the cell has grown to the correct size
2-There is a check to see if there is any damaged cells
Metaphase/Spindle checkpoint
Takes place before the mitotic stage. There is a check to see if the chromosomes are aligned on the mitotic spindle. If they are aligned properly, mitosis and cytokinesis can take place. However if they are not aligned properly, mitosis and cytokinesis cannot take place.
G0 phase
G0 is when cell cycle arrest happens and is entered for 3 reasons:
1-When the cell has been fully differentiated e.g. adult neurons
2-If they have damaged DNA e.g. senescent cells
3-B-memory cells