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TF > Antidepresivos ISRS > Flashcards

Antidepresivos ISRS Flashcards

1
Q

Actúan mayormente sobre vías

A

5HT (serotonins)

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2
Q

Lapso terapéutico requerido para funcionar

A

Mayor a 4 semanas

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3
Q

1 Locus ceruleus
2 Sustancia gris periacueductal
3 Medula rostro ventral

A

1NE
2 Opioides
3 Serotonina

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4
Q

Los antidepresivo generan solo abstinencia

A

verdadero

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5
Q

Efectos crónicos

A

Aumento de neuronas (BDNF) e incrementan actividad presináptica de neuronas del RAFE

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6
Q

Inhibidores selectivos de la recaptura de Serotonina (ISRS)

A

FLUOXETINA, Paroxetina, SERTRALINA, Fluvoxamina, CITALOPRAM, Escitalopram

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7
Q

ISRS mecanismo de acción

A

Inhiben a a SERT (transportador 5TH) Aumento de 5TH en hendidura

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8
Q

ISRS indicaciones

A

TOC, DEPRESIÓN MAYOR, TRANSTORNO DE ANSIEDAD, TEPT( trastorno por estrés postraumático), POSTMENOPAUSIA, BULIMIA, SINDROME DISFORICO PREMENSTRUAL

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9
Q

ADMINISTRACIÓN

A

ORAL

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10
Q

VD ALTO CRUZAN

A

PLACENTA, BHE, LECHE MATERNA

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11
Q

EXCRECIÓN

A

RENAL Y HEPÁTICA

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12
Q

ISRS efectos adversos

Mutagénicos tipo

A

Insomnio, irritabilidad, somnolencia, cefalea, fatiga, disminución del lívido, problemas eyaculatorios, alteración del GI

C

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13
Q

Antídoto de síndrome serotoninérgico (bloquea 5HT2)

A

Ciproheptadina

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14
Q

Al interaccionar con otros serotoninérgicos como ______ puede causar____

A

IMAO, Triptanos, tramadol, éxtasis / síndrome serotoninérgico

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15
Q

ISRS Inhibidor deL CITOCROMO
Vigilar con

A

CYP2D6
antiarritmicos C1

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16
Q

Característica principal del síndrome serotoninérgico (predominio simpático)
-Clonus

A

Hiperreflexia
-(muchas contracciones)

17
Q

ISRS para pacientes con enfermedad hepática

A

Sertralina

18
Q

Utilizado principalmente en TOC y anorexia nerviosa

A

Fluoxetina

19
Q

Puede causar arritmias y ya no se usa

A

Citalopram

20
Q

ISRS DISPONIBLES EN MÉXICO

A

SERTRALINA, FLUOXETINA, CITALOPRAM

TF (38 decks)

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