Anesthesia Flashcards
ASA Scale
American Society of Anesthesiologists
* assessment for anesthetic risk
* scale I-V; also E
ASA Scale
I
Minimal risk
* normal / healthy patient
* routine: spays and neuters
ASA Scale
II
Slight risk
* mild systemic issues
* cruciate repairs / neonates and geriatrics
ASA Scale
III
Moderate risk
* moderate systemic issues / disease with mild C/S
* murmurs, anemia, ect
ASA Scale
IV
High risk
* severe systemic issues that are life threatening
* shock or gastric torsion
ASA Scale
V
Extreme risk
* surgery to save life - will die otherwise
* shock / organ failure / trauma
ASA Scale
E
Emergency
* any previous risk class presenting for immediate surgery
Preanesthetic Drugs
Classes
- Anticholinergics
- Tranquilizers / Sedatives
- Opioids
- Neuroleptanalgesics
Anticholinergics
Block actions of PNS (acetylcholine)
* Atropine and Glycopyrrolate
* prevent / treat bradycardia
* may cause tachycardia - do not give if preexisting heart condition
* mydriatic (dilates pupils)
* slows GI movement - don’t use if constipated
* not for use in rabbits
Atropine
- Anticholinergic
- Faster and more potent than Glycopyrrolate
- Crosses blood-brain and placental barriers
- IV = ventricular arrhythmias
- Reversed with physostigmine
Glycopyrrolate
- Anticholinergic
- Slower and less potent than Atropine, but works longer
- Does not cross blood-brain or placental barriers
Tranquilizers / Sedatives
- Tranquilizer: calms anxiety without necessarily sedating
- Sedation: reduces mental activity
- Phenothiazines
- Benzodiazepines
- Butyrophenones
- Alpha 2 Agonists
Phenothiazines
- Tranquilizers / Sedatives
- Block dopamine receptors in brain
- No analgesia
- Depression effects
- Can cause penile paralysis in horses
- Example: acepromazine
Benzodiazepines
- Tranquilizers / Sedatives
- Bind to GABA receptors in brain - reduces brain activity
- Metabolized in liver - do not use if has condition
- Examples: Diazepam / Midazolam
- Reversed with Flumazenil
Diazepam
- Benzodiazepine
- Not water soluble - do not mix with others
- Not taken well IM
- Can increase appetite in cats and ruminants
- Combine with Ketmaine for induction
Midazolam
- Benzodiazepine
- Water soluble - can be mixed with others
- Can be given IM or IV
Alpha 2 Agonists
- Tranquilizers / Sedatives
- Stimulates receptors to reduce norepinephrine release
- CNS depression
- Depressed RR and HR (pale MM)
- Profound sedation with moderate analgesia
- Can be added with opioids to enhance sedation / analgesia
- Examples: Xylazine and Dexmedetomidine
Xylazine
- Alpha 2 Agonist
- Trade Name: Rompun
- Used in both large and small animals - common for large
- Reversal: Yohimbine
Dexmedetomidine
- Alpha 2 Agonist
- Trade Name: Dexdomitor
- Can be used as CRI
- Reversal: Atipamezole (Antisedan)
Opioids
Classified depending on what receptor they effect in brain
* receptors: mu, delta, kappa
* most are Schedule II drugs
* used for analgesia / anesthesia / CRI
* depression of HR and RR dose dependant
Opioids
Pure (mu) Agonist
Stimulate all opioid receptors
* morphine
* hydromorphone
* fentanyl
Opioids
Mixed Agonists-Antagonists
Block one type of receptor while stimulating another
* butorphanol
* buprenorphine
Opioids
Pure Antagonists
Reverse effects of pure and mixed agonists
* provide little effect of their own
* naloxone
Neuroleptanalgesics
Any combination of an opioid analgesic and a tranquilizer
* enhances CNS depression effects from both
* mix drugs or give separately
* used when heavy sedation for short periods needed or cases of cardiac / shock
Barbiturates
- Cause sedation / muscle relaxation
- CNS depression - works on neurons and GABA
- Nonreversible - give to effect
- Metabolized via liver
- Examples: Pentobarbital and Thiopental
Pentobarbital
- Barbiturate
- Previously used for anesthesia - now common for seizure control