7. Megaloblastic Anemias

Question 1

1.The pathophysiology of megaloblastic anemia is:
a. Defective RNA synthesisand abnormal cytoplasm maturation
b. Defective DNA synthesis and abnormal nuclear matu-ration
c. Defective RNA synthesis and abnormal nuclear matu-ration
d. Defective DNA synthesis and abnormal cytoplasm maturation

Answer 1

b. Defective DNA synthesis and abnormal nuclear matu-ration

Question 2

2. Which of the following laboratory findings coincide with megaloblastic anemia?
   a. Increased serum iron and serum bilirubin
   b. Decreased serum iron and serum bilirubin
   c. Decreased serum muramidase
   d.Increased haptoglobin

Answer 2

a. Increased serum iron and serum bilirubin

Question 3

3. Megaloblastic anemia is associated with:

a. Ineffective erythropoiesis and increased reticulocytes
b. Ineffective erythropoiesis and decreased reticulocytes
c. Ineffective erythropoiesis and decreased LDH
d. Ineffective erythropoiesis and decreased erythropoietin

Answer 3

b. Ineffective erythropoiesis and decreased reticulocytes

Question 4

4. According to the morphological classification of ane-mias,megaloblastic anemia is a:

a.Macrocytic, hypochromic anemia
b.Macrocytic, hyperchromic anemia
c.Macrocytic, normochromic anemia
d. Normocytic, normochromic anemia

Answer 4

c.Macrocytic, normochromic anemia

Question 5

5.Which of the following are not seen on the peripheral smear of a patient with megaloblastic anemia?

a.Macro-ovalocytes
b. Hypersegmented neutrophils
c.Hyposegmented neutrophils
d.Howell-Jolly bodies

Answer 5

c.Hyposegmented neutrophils

Question 6

6.Which of the following are the characteristic findings of the bone marrow in a patient with megaloblastic anemia?

a.Hypocellular with low M:E ratio
b. Hypercellular with high M:E ratio
c.Hypocellular with high M:E ratio
d.Hypercellular with low M:E ratio

Answer 6

d.Hypercellular with low M:E ratio

Question 7

7.The glycoprotein necessary for absorption of vitamin B12 is:

a.Albumin
b.Transcobalamin II
c.Haptoglobin
d.Intrinsic factor

Answer 7

d.Intrinsic factor

Question 8

8.Which of the following are clinical manifestations of both B12 deficiency and folate deficiency?
a.Anemia and jaundice
b.Thrombocytosis
c.Hemoglobinemia
d.Hemoglobinuria

Answer 8

a.Anemia and jaundice

Question 9

9.Which of the following Schilling test results corresponds to a diagnosis of pernicious anemia?
a.Part I abnormal,part II not corrected
b.Part I abnormal,part II corrected
c. Part I and part II abnormal
d.Part I normal,part II corrected

Answer 9

b.Part I abnormal,part II corrected

Question 10

10.Which of the following is not a cause of vitamin B12deficiency?
a.Atrophic gastritis
b.Total gastrectomy
c.Blind loop syndrome
d.Chronic glossitis

Answer 10

d.Chronic glossitis

Question 11

11. Macrocytosis associated with acute blood loss is charac-terized by:
    a.Decreased reticulocyte count
    b.Increased reticulocyte count
    c.Pancytopenia
    d.Macro-ovalocytes

Answer 11

b.Increased reticulocyte count

Question 12

12.Which of the following is associated with pernicious anemia and not macrocytic anemia due to liver disease?

a.Increased LD
b. Increased bilirubin
c.Increased MCV
d.Hypersegmented neutrophils

Answer 12

d.Hypersegmented neutrophils