26. Disorders of Plasma Clotting Factors

Question 1

1.which of the following can lead to impairment of the
a. Decreased factor synthesis
b.Interference by abnormal molecules
c.Loss, consumption, or inactivation of factors
d. All of the above

Answer 1

d. All of the above

Question 2

2.Which of the following shows decreased activity of F VIII:C?
a. Hemophilia A
b. Hemophilia B
c.Parahemophilia
d.Hemophilia C

Answer 2

a. Hemophilia A

Question 3

3.Which of the following shows decreased activity of F VIII:C, vWF:Ag, and vWFR:Co,and a prolonged bleed-ing time test?

a.Thrombocytopenia
b.von Willebrand disease
c. Hemophilia A
d. Acquired hemophilia

Answer 3

b.von Willebrand disease

Question 4

4. The lysis of a clot in a 5 M urea solution is an indication of which disorder?
   a.Dysfibrinogenemia
   b.F XIII deficiency
   c.Antiphospholipid antibody syndrome
   d.Factor V Leiden

Answer 4

b.F XIII deficiency

Question 5

5.The factor deficiency that produces a normal aPTT and an abnormal PT is:
a.Afibrinogenemia
b.Prekallikrein
c.Factor VII
d. Factor X

Answer 5

c.Factor VII

Question 6

6.A patient with amyloidosis can have a deficiency of which factor?
a. Factor V
b.Factor X
c.Factor VIII:C
d. Factor II

Answer 6

b.Factor X

Question 7

7.The reptilase time will be normal in the presence of:
a. Heparin
b. Dysfibrinogenemia
c. Afibrinogenemia
d. Hypofibrinogenemia

Answer 7

a. Heparin

Question 8

8. Which of the following is not considered a test for iden-tification of a lupus anticoagulant?
   a. Platelet neutralization procedure(PNP)
   b. Anticardiolipin antibodies
   c. Diluted Russell’s viper venom time (dRVVT)
   d. Hexagonal phospholipid aPTT

Answer 8

b. Anticardiolipin antibodies

Question 9

9.All of the following sttements are true regarding the detection of a lupus anticoagulant(LAC) except:
a.Platelet-poor plasma samples are required.
b.The aPTT is frequently prolonged and is usually the first indication of a LAC.
c.A mixture of patient plasma with pooled normal plasma will correct the prolonged aPTT.
d. The diluted Russell’s Viper Venom Time may be used to confirm the presence of L

Answer 9

c.A mixture of patient plasma with pooled normal plasma will correct the prolonged aPTT.

Question 10

10.Activated protein C resistance:
a. Is the result of a single point mutation of the F V gene in 90% of cases;
b. Leads to increased thrombin generation as a result of impaired F V inactivation;
c.Is found in 20% to 60% of patients with venous thrombosis;
d.All of the above

Answer 10

d.All of the above