2.Bone Marrow

Question 1

1.The average life spans of red cells, neutrophils, and platelets in the circulation are:
a. 120 days, 7 days, and 10 days
b.30 days,7 days,and 10 days
c.120 days,6-10 hours, and 10 days
d. 30 days,6-10 hours, and 10 hours

Answer 1

c.120 days,6-10 hours, and 10 days

Question 2

2. Bone marrow aspirate smears are more informative than the bone core biopsy in the diagnosis and classification of:
   a. Granulomatous diseases
   b. Acute leukemias
   c. Metastatic carcinomas
   d. Gaucher’s disease

Answer 2

b. Acute leukemias

Question 3

3. The least reliable specimen on which to perform an iron stain is:
   a.Core biopsy
   b.Clot section
   c. Aspirate smears
   d. Particle preparation

Answer 3

a.Core biopsy

Question 4

4. Occasionally, nonhematopoietic cells are seen in marrow aspirates. Which of the following is most likely to be misidentified as a megakaryocyte?

a.Reticular cell
b. Storage histiocyte
c.Osteoclast
d. Endothelial cell

Answer 4

c.Osteoclast

Question 5

5. If the aspirate is unsuccessful (i.e., a “dry tap”),which alternative processing steps are possible?

a.An extra core biopsy can be obtained and placed in saline or RPMI for flow cytometricstudies.

b. Touch preparations of the core biopsy can be used for Wright-Giemsa morphologic evaluation.

c. Touch preparations of the core biopsy can be used for FISH studies and/or cytochemical stains.

d.All of the above

Answer 5

d.All of the above

Question 6

6. In early childhood up to one third of the cellularity can be comprised of the following cells:
   a.Erythroblasts
   b.Granulocytic precursors
   c.Lymphocytes
   d.Histiocytes-monocytes

Answer 6

c.Lymphocytes

Question 7

7.When is a bone marrow study not indicated?

a.When circulating blasts are seen on the peripheral smear
b.For pancytopenia
c. In thrombocytopenia with no apparent cause
d. In iron deficiency anemia

Answer 7

d. In iron deficiency anemia

Question 8

8. Which is true for hematogones?
   a.They are malignant cells.
   b.They belong to the granulocytic series.
   c. Morphologically they mimic blasts of lymphoblastic leukemia.
   d. They are most commonly seen in elderly individuals.

Answer 8

c. Morphologically they mimic blasts of lymphoblastic leukemia.

Question 9

9. Which is/are true for lymphoid aggregates?

a.Paratrabecular lymphoid aggregates are usually malignant.
b.Benign aggregates are usually nonparatrabecular.
c. Reactive lymphoid aggregates commonly have a blood vessel and plasma cells at the periphery.
d.All of the above.

Answer 9

d.All of the above.

Question 10

10. The most appropriate site for bone marrow studies in adults is:

a. Anterior superior iliac crest
b.Posterior superior iliac crest
c.Sternum
d.Tibia

Answer 10

b.Posterior superior iliac crest