28. Introduction to Thrombosis and Anticoagulant Therapy

Question 1

1.Which characteristic of endothelial cells suppresses fibrinolysis?
a.Platelet adhesion
b. Production of t-PA inhibitor
c. Secretion of von Willebrand’s factor
d. Release of tissue factors

Answer 1

b. Production of t-PA inhibitor

Question 2

2.Which of the following statements concerning warfarin is true?
a. It inhibits production of contact coagulation factors
b. It decreases the function of vitamin K-dependent factors.b.Antithrombin
c.It interferes with cyclic vitamin K before carboxylation.
d. It will inhibit coagulation in a standard tube of blood.

Answer 2

b. It decreases the function of vitamin K-dependent factors.

Question 3

3.Which cell plays a key role in the regulation of hemostasis?
a.Endothelial cell
b.Neutrophil
c.Fibroblast
d.Eosinophil
e.Erythrocyte

Answer 3

a.Endothelial cell

Question 4

4.A 28-year-old man suffered from recurrent deep venous thrombosis and pulmonary embolus. Studies in the labo-ratory show that his plasma is unable to inhibit factors VIIIa and Va, indicating the plasma is deficient in which naturally occurring inhibitor/anticoagulant?
a.Protein C
b.Antithrombin
c. High-molecular-weight kininogen
d.Ferrochelatase
e.Fibronectin

Answer 4

a.Protein C

Question 5

5.A 28-year-old woman with known systemic lupus ery-thematosus presents with a swollen painful left leg. She had had one prior deep venous thrombosis. She has no laboratory test do you expect to be often abnormal?
a. Thrombin time
b.Activated partial thromboplastin time
c.Assay for factor V
d.Assay for plasminogen
e.Assay for antithrombin

Answer 5

b.Activated partial thromboplastin time

Question 6

6. A 25 year old woman presents with a thrombus in her right leg.She had a similar event 2 years ago in te left monary thromboembolus. Of the following potential eti-ologies;which is the most likely?
   a. Protein S deficiency
   b.Antithrombin deficiency
   c.Hyperhomocysteinemia
   d. Factor V Leiden
   e.Factor XI deficiency

Answer 6

d. Factor V Leiden

Question 7

7.What is the most common cause of activated protein C resistance?
a.Functional PS deficiency
b. Inhibitors of activated protein C
c. Factor V Leiden
d. Mutated forms of factors V and VIII

Answer 7

c. Factor V Leiden

Question 8

8. What is the most significant inhibitor of tissue plasmino-gen activator?
   a.Plasminogen activator inhibitor-1
   b. Plasminogen activator inhibitor-2
   c. Plasminogen activator inhibitor-3
   d. Plasminogen activator inhibitor-4

Answer 8

a.Plasminogen activator inhibitor-1

Question 9

9.What is the major inhibitor of thrombin and factor Xa?
a. Protein C
b.Antithrombin
c. Protein S
d. Heparin cofactor II

Answer 9

b.Antithrombin

Question 10

10.Which of the following is not a thrombolytic agent?
a. Tissue plasminogen activator
b. Urokinase
c. Streptokinase
d. α2-Antiplasmin

Answer 10

d. α2-Antiplasmin